Can autophagy promote longevity? (Q34135551)

31 July 2017

Can autophagy promote longevity? (English)

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31 July 2017

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Nektarios Tavernarakis

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2

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31 July 2017

3

Guido Kroemer

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author name string

Frank Madeo

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1

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31 July 2017

1 September 2010

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31 July 2017

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31 July 2017

12

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31 July 2017

842-846

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31 July 2017

9

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https://scigraph.springernature.com/pub.10.1038/ncb0910-842

31 July 2017

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cites work

Autophagy is required for dietary restriction-mediated life span extension in C. elegans

1 reference

https://api.crossref.org/works/10.1038%2FNCB0910-842

Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0910-842

Autophagy is required for extension of yeast chronological life span by rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0910-842

Permeases recycle amino acids resulting from autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0910-842

Molecular regulation of apoptosis in fast plantaris muscles of aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0910-842

Rapamycin decelerates cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0910-842

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0910-842

Autophagy regulates ageing in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0910-842

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

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12 December 2020

Recent developments in yeast aging

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12 December 2020

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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12 December 2020

Efficient cross-presentation depends on autophagy in tumor cells

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12 December 2020

Divergent roles of RAS1 and RAS2 in yeast longevity

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12 December 2020

Regulation of autophagy by cytoplasmic p53

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12 December 2020

Defective autophagy leads to cancer

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12 December 2020

Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation.

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12 December 2020

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12 December 2020

The life span-prolonging effect of sirtuin-1 is mediated by autophagy

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12 December 2020

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12 December 2020

Induction of autophagy by spermidine promotes longevity

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12 December 2020

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

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12 December 2020

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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12 December 2020

Inhibition of macroautophagy triggers apoptosis

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12 December 2020

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

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12 December 2020

Sirtuins in aging and age-related disease.

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12 December 2020

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

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12 December 2020

Autophagy and aging: the importance of maintaining "clean" cells

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12 December 2020

Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries

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12 December 2020

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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12 December 2020

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

1 reference

12 December 2020

Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking

1 reference

12 December 2020

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

12 December 2020

Autophagy for the avoidance of neurodegeneration

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12 December 2020

The roles of intracellular protein-degradation pathways in neurodegeneration

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12 December 2020

Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina

1 reference

12 December 2020

Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.

1 reference

12 December 2020

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

1 reference

12 December 2020

Eating to exit: autophagy-enabled senescence revealed.

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12 December 2020

The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death

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12 December 2020

Autophagy genes are essential for dauer development and life-span extension in C. elegans

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12 December 2020

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

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12 December 2020

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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12 December 2020

Extension of chronological life span in yeast by decreased TOR pathway signaling

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12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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12 December 2020

Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

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12 December 2020

Cytoprotective roles for autophagy

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12 December 2020

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

1 reference

12 December 2020

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

1 reference

12 December 2020

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

1 reference

12 December 2020

The ongoing saga of sirtuins and aging

1 reference

12 December 2020

Resveratrol is not a direct activator of SIRT1 enzyme activity

1 reference

12 December 2020

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

1 reference

12 December 2020

Histone H4 lysine 16 acetylation regulates cellular lifespan

1 reference

12 December 2020

Autophagic cell death: the story of a misnomer

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12 December 2020

Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart.

1 reference

12 December 2020

Decoding cell death signals in inflammation and immunity

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12 December 2020

The effects of p53 on whole organism longevity are mediated by autophagy

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12 December 2020

Polyamine-rich food decreases age-associated pathology and mortality in aged mice

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12 December 2020

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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12 December 2020

Autophagy mediates the mitotic senescence transition

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12 December 2020

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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12 December 2020

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans

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12 December 2020

Autophagy in the Pathogenesis of Disease

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12 December 2020

Resveratrol improves health and survival of mice on a high-calorie diet

1 reference

12 December 2020

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

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12 December 2020

Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

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12 December 2020

Autophagy suppresses tumorigenesis through elimination of p62

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12 December 2020

Loss of autophagy in the central nervous system causes neurodegeneration in mice

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12 December 2020

Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index

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12 December 2020

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

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12 December 2020

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12 December 2020

Sir2 blocks extreme life-span extension.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCB0910-842

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PubMed ID

20811357

Dimensions Publication ID

31 July 2017

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1 reference

PubMed ID

20811357