Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance (Q34135404)

31 July 2017

title

Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance (English)

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31 July 2017

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Shigeo Ohba

1

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31 July 2017

Joydeep Mukherjee

series ordinal

2

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31 July 2017

Wendy L See

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3

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31 July 2017

Russell O Pieper

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4

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31 July 2017

language of work or name

English

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publication date

17 July 2014

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31 July 2017

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31 July 2017

volume

74

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31 July 2017

issue

17

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31 July 2017

page(s)

4836-4844

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Lactate dehydrogenase A silencing in IDH mutant gliomas

31 July 2017

cites work

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5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.

5 July 2018

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5 July 2018

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Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage

5 July 2018

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An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

5 July 2018

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An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

5 July 2018

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5 July 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

5 July 2018

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Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways

5 July 2018

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Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

5 July 2018

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DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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S6K1 plays a key role in glial transformation

5 July 2018

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5 July 2018

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The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity

5 July 2018

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Homologous recombination is required for AAV-mediated gene targeting

5 July 2018

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Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

5 July 2018

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Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase

5 July 2018

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Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154998

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154998

Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154998

AGAR SUSPENSION CULTURE FOR THE SELECTIVE ASSAY OF CELLS TRANSFORMED BY POLYOMA VIRUS.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154998

Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154998

Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154998

Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154998

p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154998

10.1158/0008-5472.CAN-14-0924

28 October 2018

Identifiers

DOI

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31 July 2017

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31 July 2017

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