Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect. (Q34128868)

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English	Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect.	scientific article

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5 February 2020

Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect (English)

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5 February 2020

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5 February 2020

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5 February 2020

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Saisudha Koka

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5 February 2020

Shu-Guang Zhu

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5 February 2020

David Durrant

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5 February 2020

Rakesh C Kukreja

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5 February 2020

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11 June 2010

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5 February 2020

Journal of Pharmacology and Experimental Therapeutics

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5 February 2020

334

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5 February 2020

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5 February 2020

1023-1030

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5 February 2020

Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939673

5 July 2018

cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium

1 reference

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5 July 2018

Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939673

5 July 2018

Tadalafil pharmacokinetics in healthy subjects

1 reference

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5 July 2018

Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity

1 reference

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5 July 2018

Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity

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5 July 2018

Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity

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5 July 2018

Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart.

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5 July 2018

Selective phosphodiesterase type 5 inhibition using tadalafil for the treatment of erectile dysfunction

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5 July 2018

Anthracycline-related toxicity requiring cardiac transplantation in long-term disease-free survivors with acute promyelocytic leukemia

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5 July 2018

Phosphodiesterase 5 inhibitors: current status and potential applications

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5 July 2018

Adriamycin-induced heart failure: mechanism and modulation

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5 July 2018

Mechanism of doxorubicin-induced inhibition of sarcoplasmic reticulum Ca(2+)-ATPase gene transcription

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5 July 2018

Anthracyclines in the treatment of cancer. An overview

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5 July 2018

The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice

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5 July 2018

A clinicopathologic analysis of adriamycin cardiotoxicity

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5 July 2018

Effects of first-dose doxorubicin on cardiac rhythm as evaluated by continuous 24-hour monitoring.

1 reference

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5 July 2018

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

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5 July 2018

Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms

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5 July 2018

A new insight into adriamycin-induced cardiotoxicity

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5 July 2018

Anthracycline cardiomyopathy monitored by morphologic changes

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Protective effects of tadalafil on experimental spinal cord injury in rats

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28 October 2018

Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice

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28 October 2018

Sildenafil citrate concentrations not affecting oxidative phosphorylation depress H2O2 generation by rat heart mitochondria

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28 October 2018

Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy.

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28 October 2018

Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte

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28 October 2018

The phosphodiesterase-5 inhibitor tadalafil reduces myocardial infarct size

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28 October 2018

Vardenafil: a novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits

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Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

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28 October 2018

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28 October 2018

Protective effect of arabic gum against cardiotoxicity induced by doxorubicin in mice: a possible mechanism of protection

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Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits

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28 October 2018

Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability

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Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response

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12 December 2020

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Comparative metabolism and pharmacokinetics of doxorubicin and 4'-epidoxorubicin in plasma, heart and tumor of tumor-bearing mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20543097

12 December 2020

based on heuristic

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Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20543097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxorubicin-induced cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20543097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20543097

12 December 2020

based on heuristic

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Prediction and prevention of chemotherapy-induced cardiomyopathy: can it be done?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20543097

12 December 2020

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10.1124/JPET.110.170191

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5 February 2020

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5 February 2020

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5 February 2020

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