Agomelatine, the first melatonergic antidepressant: discovery, characterization and development (Q34122643)

31 July 2017

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title

Agomelatine, the first melatonergic antidepressant: discovery, characterization and development (English)

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31 July 2017

Christian de Bodinat

1

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31 July 2017

Béatrice Guardiola-Lemaitre

2

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31 July 2017

Elisabeth Mocaër

3

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31 July 2017

Pierre Renard

4

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31 July 2017

Carmen Muñoz

5

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31 July 2017

Mark J Millan

6

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31 July 2017

25 June 2010

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Nature Reviews Drug Discovery

31 July 2017

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31 July 2017

9

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31 July 2017

628-642

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31 July 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrd3140

31 July 2017

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31 March 2020

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Entrainment of circadian rhythms by S-20098, a melatonin agonist, is dose and plasma concentration dependent

31 March 2020

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31 March 2020

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Melatonin and its new agonist S-20098 restore synchronized sleep fragmented by experimental trypanosome infection in the rat.

31 March 2020

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Resynchronisation of a diurnal rodent circadian clock accelerated by a melatonin agonist

31 March 2020

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31 March 2020

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Entrainment of rat circadian rhythms by the melatonin agonist S-20098 requires intact suprachiasmatic nuclei but not the pineal.

31 March 2020

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Organization of rat circadian rhythms during daily infusion of melatonin or S20098, a melatonin agonist

31 March 2020

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Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

31 March 2020

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Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis

31 March 2020

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Early evening melatonin and S-20098 advance circadian phase and nocturnal regulation of core body temperature

31 March 2020

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Regulation of serotonin-2C receptor G-protein coupling by RNA editing

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Beyond the monoaminergic hypothesis: agomelatine, a new antidepressant with an innovative mechanism of action

31 March 2020

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Effect of agomelatine in the chronic mild stress model of depression in the rat.

31 March 2020

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Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

31 March 2020

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Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis

31 March 2020

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Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus.

31 March 2020

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Antidepressant action of agomelatine (S 20098) in a transgenic mouse model

31 March 2020

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31 March 2020

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31 March 2020

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Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model.

31 March 2020

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Effects of melatonin receptor ligands on swim test immobility

31 March 2020

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Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating.

31 March 2020

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Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep-wake cycle architecture

31 March 2020

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Antidepressants and sleep: a qualitative review of the literature

31 March 2020

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Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men.

31 March 2020

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Agomelatine in the treatment of major depressive disorder: potential for clinical effectiveness

31 March 2020

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Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT(2C) antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study

31 March 2020

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Pretreatment neurophysiological and clinical characteristics of placebo responders in treatment trials for major depression

31 March 2020

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Antidepressants and the placebo response

31 March 2020

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Placebo-controlled trial of agomelatine in the treatment of major depressive disorder

31 March 2020

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Improvement in subjective sleep in major depressive disorder with a novel antidepressant, agomelatine: randomized, double-blind comparison with venlafaxine

31 March 2020

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Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline

31 March 2020

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A double-blind comparison of sexual functioning, antidepressant efficacy, and tolerability between agomelatine and venlafaxine XR.

31 March 2020

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Pathophysiology of depression: role of sleep and the melatonergic system

31 March 2020

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Agomelatine prevents relapse in patients with major depressive disorder without evidence of a discontinuation syndrome: a 24-week randomized, double-blind, placebo-controlled trial

31 March 2020

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Absence of discontinuation symptoms with agomelatine and occurrence of discontinuation symptoms with paroxetine: a randomized, double-blind, placebo-controlled discontinuation study

31 March 2020

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Discontinuation symptoms in depression and anxiety disorders

31 March 2020

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Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis

31 March 2020

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Acute low doses of melatonin restore full sexual activity in impotent male rats

31 March 2020

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Melatonin protects against the effects of chronic stress on sexual behaviour in male rats

31 March 2020

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Dopamine and serotonin: influences on male sexual behavior

31 March 2020

1 reference

Better sexual acceptability of agomelatine (25 and 50 mg) compared with paroxetine (20 mg) in healthy male volunteers. An 8-week, placebo-controlled study using the PRSEXDQ-SALSEX scale.

31 March 2020

1 reference

Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants

31 March 2020

1 reference

Sleep, memory, and plasticity

31 March 2020

1 reference

Adult hippocampal neurogenesis, synaptic plasticity and memory: facts and hypotheses

31 March 2020

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Circadian rhythms and memory: not so simple as cogs and gears

31 March 2020

1 reference

Cognitive deficits in depression: possible implications for functional neuropathology

31 March 2020

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The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats

31 March 2020

1 reference

Prevalence of depressive symptoms and syndromes in later life in ten European countries: the SHARE study.

31 March 2020

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The diagnosis, symptomatology, and epidemiology of seasonal affective disorder.

31 March 2020

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Agomelatine in the treatment of seasonal affective disorder

31 March 2020

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Managing the patient with co-morbid depression and an anxiety disorder

31 March 2020

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Anxiolytic-like action of the antidepressant agomelatine (S 20098) after a social defeat requires the integrity of the SCN.

31 March 2020

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Serotonin 5-HT(2C) receptors regulate anxiety-like behavior

31 March 2020

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Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade

31 March 2020

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Efficacy of agomelatine in generalized anxiety disorder: a randomized, double-blind, placebo-controlled study

31 March 2020

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Melatonin in mood disorders

31 March 2020

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Circuit projection from suprachiasmatic nucleus to ventral tegmental area: a novel circadian output pathway

31 March 2020

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Melatonin or a melatonin agonist corrects age-related changes in circadian response to environmental stimulus

31 March 2020

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12 December 2020

Nonpharmacological, somatic treatments of depression: electroconvulsive therapy and novel brain stimulation modalities

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12 December 2020

SNRIs: their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants

1 reference

12 December 2020

Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors.

1 reference

12 December 2020

Multi- and single-target agents for major psychiatric diseases: therapeutic opportunities and challenges.

1 reference

12 December 2020

Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies

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12 December 2020

Tolerability of modern antidepressants

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12 December 2020

Efficacy of agomelatine, a MT1/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder

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12 December 2020

New naphthalenic ligands of melatoninergic receptors

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12 December 2020

Major depressive disorder, sleep EEG and agomelatine: an open-label study.

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12 December 2020

Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders

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12 December 2020

Weight gain in the treatment of mood disorders

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12 December 2020

Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety

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12 December 2020

Identifiers

DOI

10.1038/NRD3140

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Dimensions Publication ID

31 July 2017

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