Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment (Q34122409)

31 July 2017

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title

Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment (English)

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31 July 2017

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M Pirmohamed

3

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Dean J Naisbitt

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ORCID Public Data File 2021

author name string

D J Naisbitt

series ordinal

1

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31 July 2017

S F Gordon

series ordinal

2

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31 July 2017

B K Park

series ordinal

4

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31 July 2017

1 December 2000

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31 July 2017

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31 July 2017

23

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31 July 2017

483-507

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31 July 2017

6

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https://scigraph.springernature.com/pub.10.2165/00002018-200023060-00002

31 July 2017

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cites work

Treatment of severe drug eruptions

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Glutathione deficiency and human immunodeficiency virus infection

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12 December 2020

Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers

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CD8+ myelin peptide-specific T cells can chemoattract CD4+ myelin peptide-specific T cells: importance of IFN-inducible protein 10

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Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity.

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Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells

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12 December 2020

Sulfamethoxazole is metabolized to the hydroxylamine in humans

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12 December 2020

Current trends in drug-induced autoimmunity

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12 December 2020

Interleukin-4 plays a dominant role in Th1- or Th2-like responses during the primary immune response to the hapten penicillin

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12 December 2020

Costimulatory regulation of T cell function.

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12 December 2020

Mechanisms of autoantibody formation and chemically-induced autoimmunity

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12 December 2020

Role of T cells in drug allergies

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12 December 2020

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

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12 December 2020

An innate sense of danger

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12 December 2020

Class II antigen processing compartments and the function of HLA-DM.

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12 December 2020

Prostaglandin E2and IL-4 Provide Naive CD4+T Cells with Distinct Inhibitory Signals for the Priming of IFN-γ Production

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12 December 2020

The study of xenobiotic-metabolizing enzymes and their role in toxicity in vivo using targeted gene disruption

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12 December 2020

Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.

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12 December 2020

Mechanisms of drug reactions: the metabolic track

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12 December 2020

Antigen capture, processing, and presentation by dendritic cells: recent cell biological studies.

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12 December 2020

Drug disposition and drug hypersensitivity

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12 December 2020

Natural adjuvants: endogenous activators of dendritic cells

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12 December 2020

Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.

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12 December 2020

Cutaneous reactions to drugs. An analysis of spontaneous reports in four Italian regions

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12 December 2020

Penicillin Allergy: The Formation of the Penicilloyl Determinant

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12 December 2020

Biology and genetics of atopic disease

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12 December 2020

Th0 Cells in the Thymus: The Question of T-Helper Lineages

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12 December 2020

Mianserin and agranulocytosis in New Zealand.

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12 December 2020

Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals

1 reference

12 December 2020

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

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12 December 2020

T-cell response in penicillin allergy

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12 December 2020

Drug-related hospital admissions

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12 December 2020

The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution

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12 December 2020

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

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12 December 2020

Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.

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12 December 2020

Positive and negative thymocyte selection.

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12 December 2020

Peptide binding and antigen presentation by class II histocompatibility glycoproteins

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12 December 2020

The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions

1 reference

12 December 2020

A very high level of crossreactivity is an essential feature of the T-cell receptor

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12 December 2020

Idiosyncratic drug reactions: a mechanistic evaluation of risk factors

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12 December 2020

Structure and expression of murine CD30 and its role in cytokine production

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12 December 2020

Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

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12 December 2020

Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells

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12 December 2020

Glutathione S-transferases--a review.

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12 December 2020

Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms

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12 December 2020

Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection

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12 December 2020

Risk of Stevens-Johnson syndrome and toxic epider mal necrolysis during first weeks of antiepileptic therapy: a case-control study

1 reference

12 December 2020

Fatal hepatitis associated with diclofenac

1 reference

12 December 2020

Drug-induced agranulocytosis. Peripheral destruction of polymorphonuclear leukocytes and their marrow precursors

1 reference

12 December 2020

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions

1 reference

12 December 2020

Interaction of lymphocytes with Kupffer cells from halothane-exposed guinea pigs

1 reference

12 December 2020

Immunologic mechanisms of cutaneous drug reactions

1 reference

12 December 2020

Heat-shock protein T-cell epitopes trigger a spreading regulatory control in a diversified arthritogenic T-cell response.

1 reference

12 December 2020

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.

1 reference

12 December 2020

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity

1 reference

12 December 2020

Idiosyncratic reactions to antidepressants: A review of the possible mechanisms and predisposing factors

1 reference

12 December 2020

Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells

1 reference

12 December 2020

Protein-reactive metabolites of carbamazepine in mouse liver microsomes

1 reference

12 December 2020

Expression and release of LAG-3-encoded protein by human CD4+ T cells are associated with IFN-gamma production .

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12 December 2020

Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones

1 reference

12 December 2020

Cytochrome P-4502E1-dependent formation of trifluoroacetyl adducts from halothane by transduced HepG2 cells

1 reference

12 December 2020

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

1 reference

12 December 2020

The role of antigen-presenting cells in the regulation of allergen-specific T cell responses.

1 reference

12 December 2020

The role of macrophage- and dendritic cell-derived IL12 in Th1 phenotype development

1 reference

12 December 2020

Activation of mianserin and its metabolites by human liver microsomes

1 reference

12 December 2020

Coombs-positive hemolytic anemia caused by penicillin administration

1 reference

12 December 2020

Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

1 reference

12 December 2020

Glucuronidation in humans. Pharmacogenetic and developmental aspects

1 reference

12 December 2020

Adverse drug reactions

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12 December 2020

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

1 reference

12 December 2020

Th1 and Th2 in human diseases

1 reference

12 December 2020

Mechanisms of unpredictable adverse drug reactions

1 reference

12 December 2020

Antimyeloperoxidase antibodies and adverse reactions to clozapine

1 reference

12 December 2020

Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies

1 reference

12 December 2020

Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity

1 reference

12 December 2020

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12 December 2020

Mechanisms of antigen presentation

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12 December 2020

Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine

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12 December 2020

Cytotoxic activity of T cells and non-T cells from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenac

1 reference

12 December 2020

HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1 reference

12 December 2020

Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals.

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12 December 2020

CD30: expression and function in health and disease

1 reference

12 December 2020

Intracellular transport of MHC class II molecules

1 reference

12 December 2020

Idiosyncratic drug reactions: possible role of reactive metabolites generated by leukocytes

1 reference

12 December 2020

The role of CTLA-4 in the regulation and initiation of T-cell responses

1 reference

12 December 2020

Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients

1 reference

12 December 2020

Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals

1 reference

12 December 2020

Immunochemical Mechanisms of Penicillin Induced Coombs Positivity and Hemolytic Anemia in Man

1 reference

12 December 2020

Diclofenac induced hepatitis. 3 cases with features of autoimmune chronic active hepatitis

1 reference

12 December 2020

Heat shock factors and the control of the stress response

1 reference

12 December 2020

Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses

1 reference

12 December 2020

Antigen presenting cells integrate opposing signals from CD4+ and CD8+ regulatory T lymphocytes to arbitrate the outcomes of immune responses

1 reference

12 December 2020

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1 reference

12 December 2020

T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction

1 reference

12 December 2020

Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine-induced agranulocytosis

1 reference

12 December 2020

Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis

1 reference

12 December 2020

New aspects on antigens in penicillin allergy

1 reference

12 December 2020

CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes

1 reference

12 December 2020

Polymorphisms in xenobiotic conjugation and disease predisposition

1 reference

12 December 2020

Lymphocyte activation in allergic reactions elicited by small-molecular-weight compounds

1 reference

12 December 2020

A reevaluation of the clinical characteristics of clozapine-induced agranulocytosis in light of the United States experience

1 reference

12 December 2020

Accessory factors involved in murine T cell activation. Distinct roles of interleukin 6, interleukin 1 and tumor necrosis factor

1 reference

12 December 2020

Functions of CD8 T-cell subsets secreting different cytokine patterns.

1 reference

12 December 2020

Drug-protein conjugation and its immunological consequences

1 reference

12 December 2020

Cutaneous metabolism of xenobiotics

1 reference

12 December 2020

CYP enzymes and adverse drug reactions.

1 reference

12 December 2020

Virgin and memory T cells have different requirements for activation via the CD2 molecule.

1 reference

12 December 2020

Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis

1 reference

12 December 2020

1 reference

12 December 2020

Immunochemical analysis of sulfonamide drug allergy: identification of sulfamethoxazole-substituted human serum proteins

1 reference

12 December 2020

Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome

1 reference

12 December 2020

New perspectives of CD28-B7-mediated T cell costimulation

1 reference

12 December 2020

Immune response to sulfamethoxazole in patients with AIDS.

1 reference

12 December 2020

Predisposition to phenytoin hepatotoxicity assessed in vitro

1 reference

12 December 2020

Thalidomide: current and potential clinical applications

1 reference

12 December 2020

Anaphylaxis: diagnosis and treatment

1 reference

12 December 2020

Drug-induced red cell dyscrasias

1 reference

12 December 2020

The role of endosomes and lysosomes in MHC class II functioning.

1 reference

12 December 2020

The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1996. Cell mediated immunity in virus infections

1 reference

12 December 2020

Demonstration of a cellular immune response in halothane-exposed guinea pigs

1 reference

12 December 2020

Antigen processing: the gateway to the immune response

1 reference

12 December 2020

Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs

1 reference

12 December 2020

Cutaneous T-cell recruitment in toxic epidermal necrolysis. Further evidence of CD8+ lymphocyte involvement

1 reference

12 December 2020

A receptor for phosphatidylserine-specific clearance of apoptotic cells

1 reference

12 December 2020

Mechanisms of MHC class I--restricted antigen processing

1 reference

12 December 2020

Accessory molecule and costimulation requirements for CD4 T cell response

1 reference

12 December 2020

Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models

1 reference

12 December 2020

Tolerance, danger, and the extended family

1 reference

12 December 2020

New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system

1 reference

12 December 2020

Low concentrations of acid-soluble thiol (cysteine) in the blood plasma of HIV-1-infected patients.

1 reference

12 December 2020

The liver in mild halothane hepatitis. Light and electron microscopic findings with special reference to the mononuclear cell infiltrate

1 reference

12 December 2020

The Role of Active Metabolites in Drug Toxicity

1 reference

12 December 2020

Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry

1 reference

12 December 2020

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man

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12 December 2020

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell.

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12 December 2020

Distribution of cycling T lymphocytes in blood and lymphoid organs during immune responses

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12 December 2020

Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine

1 reference

12 December 2020

Differential distribution of free and bound glutathione and cyst(e)ine in human blood

1 reference

12 December 2020

Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s)

1 reference

12 December 2020

Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human alpha beta+ T cell clones.

1 reference

12 December 2020

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS.

1 reference

12 December 2020

The use of single-nucleotide polymorphism maps in pharmacogenomics

1 reference

12 December 2020

The regulation of the development of CD8 effector T cells

1 reference

12 December 2020

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

1 reference

12 December 2020

Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy

1 reference

12 December 2020

Beta-lactam crossreactivity

1 reference

12 December 2020

Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding

1 reference

12 December 2020

The costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group

1 reference

12 December 2020

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

1 reference

12 December 2020

CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40.

1 reference

12 December 2020

Maturation of human neonatal CD4+ and CD8+ T lymphocytes into Th1/Th2 effectors.

1 reference

12 December 2020

Recent advances in the understanding of interleukin-2 signal transduction

1 reference

12 December 2020

Summary of the national Halothane Study. Possible association between halothane anesthesia and postoperative hepatic necrosis

1 reference

12 December 2020

T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.

1 reference

12 December 2020

Amidopyrine agranulocytosis:drug inhibition of granulocyte colonies in the presence of patient's serum

1 reference

12 December 2020

The functional role of CD8+ T helper type 2 cells

1 reference

12 December 2020

Drug hypersensitivity reactions and human immunodeficiency virus disease

1 reference

12 December 2020

The role of reactive drug metabolites in immune-mediated adverse drug reactions

1 reference

12 December 2020

Enzymatic oxidation of xenobiotic chemicals

1 reference

12 December 2020

In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines.

1 reference

12 December 2020

Modulation of T-cell cytokine secretion by accessory cell-derived products.

1 reference

12 December 2020

Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility

1 reference

12 December 2020

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1 reference

12 December 2020

Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions.

1 reference

12 December 2020

An ABC of Drug-Related Problems

1 reference

12 December 2020

Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

1 reference

12 December 2020

Severe hypersensitivity syndrome due to sulfasalazine associated with reactivation of human herpesvirus 6

1 reference

12 December 2020

Managing drug reactions to sulfonamides and other drugs in HIV infection: desensitization rather than rechallenge?

1 reference

12 December 2020

HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.

1 reference

12 December 2020

Drug-protein conjugates—XIV

1 reference

12 December 2020

Pathogenesis and management of HIV-associated drug hypersensitivity.

1 reference

12 December 2020

Distribution of activated T cells migrating through the body: a matter of life and death

1 reference

12 December 2020

T cells ignore the parent drug propylthiouracil but are sensitized to a reactive metabolite generated in vivo

1 reference

12 December 2020

Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine

1 reference

12 December 2020

Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells.

1 reference

12 December 2020

The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergy

1 reference

12 December 2020

Immediate hypersensitivity reactions to penicillin and related antibiotics

1 reference

12 December 2020

Defective antigen processing correlates with a low level of intracellular glutathione

1 reference

12 December 2020

Role of cytokines in determining T-lymphocyte function

1 reference

12 December 2020

Drug-protein conjugates--XVII. The effect of storage on the antigenicity and immunogenicity of benzylpenicillin in the rat.

1 reference

12 December 2020

A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

1 reference

12 December 2020

Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10

1 reference

12 December 2020

The nature of the MHC class I peptide loading complex

1 reference

12 December 2020

Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine

1 reference

12 December 2020

Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982

1 reference

12 December 2020

Thrombocytopenia and leucopenia with mianserin-dependent antibodies

1 reference

12 December 2020

Transfected Drosophila cells as a probe for defining the minimal requirements for stimulating unprimed CD8+ T cells

1 reference

12 December 2020

Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns

1 reference

12 December 2020

Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents

1 reference

12 December 2020

Ticrynafen-associated hepatic injury: analysis of 340 cases

1 reference

12 December 2020

An enzyme-linked immunosorbent assay for detection of antibodies against halothane-altered hepatocyte antigens

1 reference

12 December 2020

Adverse reactions to sulphonamide and sulphonamide-trimethoprim antimicrobials: clinical syndromes and pathogenesis

1 reference

12 December 2020

The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy

1 reference

12 December 2020

Sensitivity to a metabolite of diclofenac as a cause of acute immune hemolytic anemia

1 reference

12 December 2020

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1 reference

12 December 2020

T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles.

1 reference

12 December 2020

Incidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group

1 reference

12 December 2020

Lamotrigine-induced Stevens-Johnson syndrome: demonstration of specific lymphocyte reactivity in vitro

1 reference

12 December 2020

Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance

1 reference

12 December 2020

How HLA-DM affects the peptide repertoire bound to HLA-DR molecules

1 reference

12 December 2020

HIV-related skin diseases

1 reference

12 December 2020

Severe adverse cutaneous reactions to drugs

1 reference

12 December 2020

Allergic and autoimmune reactions to xenobiotics: how do they arise?

1 reference

12 December 2020

Why positive selection?

1 reference

12 December 2020

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis

1 reference

12 December 2020

CD28/B7 costimulation: a review

1 reference

12 December 2020

Function of the transport complex TAP in cellular immune recognition

1 reference

12 December 2020

T lymphocyte differentiation in the periphery

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12 December 2020

10.2165/00002018-200023060-00002

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DOI

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Dimensions Publication ID

31 July 2017

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