Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins (Q34116053)

31 July 2017

title

Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins (English)

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31 July 2017

7

Jeffrey R Deschamps

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31 July 2017

1

Haiying Sun

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31 July 2017

Jianfeng Lu

2

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31 July 2017

Liu Liu

3

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31 July 2017

Han Yi

4

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31 July 2017

Su Qiu

5

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31 July 2017

Chao-Yie Yang

6

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31 July 2017

Shaomeng Wang

8

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31 July 2017

language of work or name

English

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publication date

1 September 2010

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Journal of Medicinal Chemistry

31 July 2017

published in

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31 July 2017

volume

53

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31 July 2017

issue

17

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31 July 2017

page(s)

6361-6367

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Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases

31 July 2017

cites work

1 reference

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SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

5 July 2018

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Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †

5 July 2018

1 reference

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

5 July 2018

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

5 July 2018

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Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

5 July 2018

1 reference

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Inhibitor of apoptosis proteins as targets for anticancer therapy

5 July 2018

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Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

5 July 2018

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Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

5 July 2018

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A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

5 July 2018

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Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

5 July 2018

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Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

5 July 2018

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Mechanism of XIAP-mediated inhibition of caspase-9

5 July 2018

1 reference

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IAP proteins: blocking the road to death's door

5 July 2018

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XIAP: apoptotic brake and promising therapeutic target.

5 July 2018

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Structural Basis of Caspase Inhibition by XIAP

5 July 2018

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

5 July 2018

1 reference

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Structural basis of IAP recognition by Smac/DIABLO

5 July 2018

1 reference

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936695

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

5 July 2018

1 reference

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

5 July 2018

1 reference

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IAP family proteins--suppressors of apoptosis

5 July 2018

1 reference

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Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936695

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936695

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

28 October 2018

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12 December 2020

Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external beta-turns

1 reference

12 December 2020

Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

1 reference

12 December 2020

Structure-based design of potent, conformationally constrained Smac mimetics

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM100487Z

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31 July 2017

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31 July 2017

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