Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF (Q34100993)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20189102%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF (English)

1 reference

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Mycobacterium tuberculosis

19 January 2020

main subject

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author

Prabagaran Narayanasamy

1

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19 January 2020

author name string

Hyungjin Eoh

2

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19 January 2020

Patrick J Brennan

3

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19 January 2020

Dean C Crick

4

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19 January 2020

publication date

1 February 2010

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19 January 2020

published in

Chemistry and Biology

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19 January 2020

volume

17

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19 January 2020

issue

2

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19 January 2020

page(s)

117-122

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A Structure-Based Approach to Ligand Discovery for 2 C -Methyl- d -erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy †

19 January 2020

cites work

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Chemoenzymatic synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol: A substrate for IspE.

5 July 2018

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The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target

5 July 2018

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Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants

5 July 2018

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Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery

5 July 2018

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The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery

5 July 2018

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Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development

5 July 2018

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Mevalonate pathway: a review of clinical and therapeutical implications

5 July 2018

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The cell-wall core of Mycobacterium tuberculosis in the context of drug discovery

5 July 2018

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Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods

5 July 2018

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1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin

5 July 2018

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Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase

5 July 2018

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Characterization of the depletion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase in Escherichia coli and Bacillus subtilis

5 July 2018

1 reference

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Structure of 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase from Haemophilus influenzae: activation by conformational transition

5 July 2018

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Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

5 July 2018

1 reference

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Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway

5 July 2018

1 reference

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Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum

5 July 2018

1 reference

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Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway

5 July 2018

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Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate

5 July 2018

1 reference

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Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

5 July 2018

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The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants

5 July 2018

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ENANTIOMERIC SYNTHESIS OF 2-C-METHYL-D-ERYTHRITOL 2, 4-CYCLODIPHOSPHATE.

5 July 2018

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Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors

28 October 2018

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Cloning and expression of IspDF from Mesorhizobium loti. Characterization of a bifunctional protein that catalyzes non-consecutive steps in the methylerythritol phosphate pathway

28 October 2018

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Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants

28 October 2018

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[2-C-Methylerythritol phosphate pathway of isoprenoid biosynthesis as a target in identifying of new antibiotics, herbicides, and immunomodulators: a review]

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20189102

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis of enantiopure 2-C-methyl-D-erythritol 4-phosphate and 2,4-cyclodiphosphate from D-arabitol

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20189102

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2010.01.013

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19 January 2020

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19 January 2020

PubMed publication ID

20189102

1 reference