Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts. (Q34099109)

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English	Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.	scientific article

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11 November 2019

Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts (English)

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11 November 2019

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murine leukemia virus

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murine leukemia virus

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Vinay K. Pathak

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11 November 2019

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Wen-Hui Zhang

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11 November 2019

Evguenia S Svarovskaia

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11 November 2019

Rebekah Barr

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15 July 2002

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11 November 2019

Proceedings of the National Academy of Sciences of the United States of America

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11 November 2019

99

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15

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11 November 2019

10090-10095

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11 November 2019

Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication

1 reference

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5 July 2018

Error-prone DNA polymerases: novel structures and the benefits of infidelity

1 reference

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5 July 2018

Intrinsic bending and deformability at the T-A step of CCTTTAAAGG: a comparative analysis of T-A and A-T steps within A-tracts

1 reference

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Structure of the replicating complex of a pol alpha family DNA polymerase

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Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

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5 July 2018

Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.

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3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1.

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A-Tract bending: insights into experimental structures by computational models

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The sequential mechanism of HIV reverse transcriptase RNase H.

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5 July 2018

Structural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switching

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5 July 2018

Development of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelity

1 reference

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5 July 2018

DNA structure and polymerase fidelity

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5 July 2018

Tyrosine 222, a member of the YXDD motif of MuLV RT, is catalytically essential and is a major component of the fidelity center.

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Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

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5 July 2018

Fidelity of mutant HIV-1 reverse transcriptases: interaction with the single-stranded template influences the accuracy of DNA synthesis

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Increased misincorporation fidelity observed for nucleoside analog resistance mutations M184V and E89G in human immunodeficiency virus type 1 reverse transcriptase does not correlate with the overall error rate measured in vitro

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A mechanism for all polymerases

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Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer

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Psi- vectors: murine leukemia virus-based self-inactivating and self-activating retroviral vectors.

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The antiretrovirus drug 3'-azido-3'-deoxythymidine increases the retrovirus mutation rate

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X-ray and solution studies of DNA oligomers and implications for the structural basis of A-tract-dependent curvature

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High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector.

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

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5 July 2018

Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase

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5 July 2018

Effects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase

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Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities

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Intrinsically bent DNA.

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Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function

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Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis

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Mutational studies of human immunodeficiency virus type 1 reverse transcriptase: the involvement of residues 183 and 184 in the fidelity of DNA synthesis

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Error-Prone DNA Polymerases

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Base substitution specificity of DNA polymerase beta depends on interactions in the DNA minor groove

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A minor groove binding track in reverse transcriptase

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The mechanism of action of T7 DNA polymerase

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Identifiers

10.1073/PNAS.152186199

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11 November 2019

2002PNAS...9910090Z

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1 reference

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11 November 2019

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11 November 2019

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