Phosphodiesterase-5 inhibition mimics intermittent reoxygenation and improves cardioprotection in the hypoxic myocardium (Q34091110)

30 July 2017

title

Phosphodiesterase-5 inhibition mimics intermittent reoxygenation and improves cardioprotection in the hypoxic myocardium (English)

1 reference

30 July 2017

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Giuseppina Milano

1

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Michele Samaja

Michele Samaja

8

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Marco Guazzi

Marco Guazzi

7

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Giuseppe Vassalli

4

Giuseppe Vassalli

1 reference

30 July 2017

Ludwig K von Segesser

5

Ludwig K von Segesser

1 reference

30 July 2017

Paola Bianciardi

2

1 reference

30 July 2017

Viviane Rochemont

3

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30 July 2017

Antonio F Corno

6

1 reference

30 July 2017

language of work or name

English

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publication date

28 November 2011

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30 July 2017

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30 July 2017

volume

6

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30 July 2017

issue

11

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30 July 2017

page(s)

e27910

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Creative Commons Attribution 4.0 International

30 July 2017

copyright license

start time

28 November 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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28 July 2018

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Preconditioning: a paradigm shift in the biology of myocardial ischemia

28 July 2018

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Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity

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28 July 2018

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Cardioprotection with phosphodiesterase-5 inhibition--a novel preconditioning strategy.

28 July 2018

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28 July 2018

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Hypoxia: unique myocardial morphology?

28 July 2018

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Daily reoxygenation decreases myocardial injury and improves post-ischaemic recovery after chronic hypoxia

21 January 2018

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Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia

21 January 2018

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Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits

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Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

21 January 2018

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Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte

21 January 2018

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Phosphodiesterase-5 inhibition abolishes neuron apoptosis induced by chronic hypoxia independently of hypoxia-inducible factor-1alpha signaling

21 January 2018

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Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation

21 January 2018

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Chronic in vivo hypoxia in various organs: hypoxia-inducible factor-1alpha and apoptosis

21 January 2018

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Nitric oxide activates the sarcolemmal K(ATP) channel in normoxic and chronically hypoxic hearts by a cyclic GMP-dependent mechanism

21 January 2018

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Cardioprotection in chronically hypoxic rabbits persists on exposure to normoxia: role of NOS and KATP channels

21 January 2018

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Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels

21 January 2018

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Responses of chronically hypoxic rat hearts to ischemia: KATP channel blockade does not abolish increased RV tolerance to ischemia

21 January 2018

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Chronic intermittent hypoxia alters Ca2+ handling in rat cardiomyocytes by augmented Na+/Ca2+ exchange and ryanodine receptor activities in ischemia-reperfusion

21 January 2018

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Intermittent hypoxia protects cardiomyocytes against ischemia-reperfusion injury-induced alterations in Ca2+ homeostasis and contraction via the sarcoplasmic reticulum and Na+/Ca2+ exchange mechanisms

21 January 2018

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The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development.

21 January 2018

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A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo

28 October 2018

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28 October 2018

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Cardioprotection with sildenafil, a selective inhibitor of cyclic 3',5'-monophosphate-specific phosphodiesterase 5.

28 October 2018

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Chronic and intermittent hypoxia induce different degrees of myocardial tolerance to hypoxia-induced dysfunction.

28 October 2018

1 reference

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Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation

28 October 2018

1 reference

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Brief reoxygenation episodes during chronic hypoxia enhance posthypoxic recovery of LV function

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22140481

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0027910

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference