Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats (Q34088598)

30 July 2017

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats (English)

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30 July 2017

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cognitive dysfunction

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Lana J Mawhinney

1

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30 July 2017

Juan Pablo de Rivero Vaccari

2

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30 July 2017

Gordon A Dale

3

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30 July 2017

Robert W Keane

4

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30 July 2017

Helen M Bramlett

5

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30 July 2017

1 December 2011

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30 July 2017

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30 July 2017

12

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30 July 2017

123

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https://scigraph.springernature.com/pub.10.1186/1471-2202-12-123

30 July 2017

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The pannexin 1 channel activates the inflammasome in neurons and astrocytes

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Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury

5 July 2018

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Immunological and inflammatory functions of the interleukin-1 family

5 July 2018

1 reference

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Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors

5 July 2018

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Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology

5 July 2018

1 reference

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Association between the interleukin-1beta polymorphisms and Alzheimer's disease: a systematic review and meta-analysis

5 July 2018

1 reference

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

5 July 2018

1 reference

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Probenecid, a gout remedy, inhibits pannexin 1 channels

5 July 2018

1 reference

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Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3.

5 July 2018

1 reference

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Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

A molecular platform in neurons regulates inflammation after spinal cord injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

The killing of neurons by beta-amyloid peptides, prions, and pro-inflammatory cytokines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process

5 July 2018

1 reference

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5 July 2018

1 reference

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Research issues in the evaluation of cognitive impairment in intensive care unit survivors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Impact of aging on hippocampal function: plasticity, network dynamics, and cognition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Inhibitors of apoptosis proteins in injury and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Acute cognitive impairment in elderly ED patients: etiologies and outcomes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Developments of a water-maze procedure for studying spatial learning in the rat

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Immunoreactive interleukin-1 beta localization in the rat forebrain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Organic anion transport in macrophage membrane vesicles

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice.

5 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

Peripheral infection and aging interact to impair hippocampal memory consolidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

Causes and prognosis of delirium in elderly patients admitted to a district general hospital.

21 January 2018

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https://api.crossref.org/works/10.1186%2F1471-2202-12-123

The risk of dementia and death after delirium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

Regulation of caspases and XIAP in the brain after asphyxial cardiac arrest in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

Systemic administration of lipopolysaccharide and interleukin-1beta have different effects on memory consolidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

21 January 2018

1 reference

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Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

Bidirectional active transport of thiosulfate in the proximal convolution of the rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

Protective effect of systemic L-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25-35) in rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-12-123

Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Apoptotic and antiapoptotic mechanisms after traumatic brain injury.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Increased expression of IL-1beta converting enzyme in hippocampus after ischemia: selective localization in microglia

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259063

Protective effect of L-kynurenine and probenecid on 6-hydroxydopamine-induced striatal toxicity in rats: implications of modulating kynurenate as a protective strategy

28 October 2018

1 reference

12 December 2020

Substrate and inhibitor specificity of anion exchangers on the brush border membrane of rabbit ileum

1 reference

12 December 2020

Systemic DL-kynurenine and probenecid pretreatment attenuates quinolinic acid-induced neurotoxicity in rats

1 reference

12 December 2020

Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system

1 reference

12 December 2020

Mechanism of organic anion transport across the apical membrane of choroid plexus

1 reference

12 December 2020

Sunburned skin activates inflammasomes

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2202-12-123

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference