Receptor-mediated targeting of gene delivery vectors: insights from molecular mechanisms for improved vehicle design (Q34076933)

30 July 2017

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title

Receptor-mediated targeting of gene delivery vectors: insights from molecular mechanisms for improved vehicle design (English)

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30 July 2017

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Douglas A. Lauffenburger

series ordinal

3

object named as

Lauffenburger DA

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30 July 2017

Varga CM

1

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PubMed ID

11064328

30 July 2017

Wickham TJ

series ordinal

2

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30 July 2017

1 December 2000

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Biotechnology and Bioengineering

30 July 2017

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30 July 2017

70

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30 July 2017

6

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30 July 2017

593-605

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A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine

30 July 2017

1 reference

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Transport pathways of macromolecules between the nucleus and the cytoplasm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Kinetics of retrovirus mediated gene transfer: the importance of intracellular half-life of retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Physiological functions of endosomal proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

A novel gene delivery system using EGF receptor-mediated endocytosis

21 January 2018

1 reference

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Lactose-poly(ethylene glycol)-grafted poly-L-lysine as hepatoma cell-tapgeted gene carrier

21 January 2018

1 reference

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Microtubular disruption prolongs the expression of human bilirubin-uridinediphosphoglucuronate-glucuronosyltransferase-1 gene transferred into Gunn rat livers

21 January 2018

1 reference

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Coupling of nuclear localization signals to plasmid DNA and specific interaction of the conjugates with importin alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels

21 January 2018

1 reference

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High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex

21 January 2018

1 reference

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Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Import of plasmid DNA into the nucleus is sequence specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

A mathematical model of the trafficking of acid-dependent enveloped viruses: application to the binding, uptake, and nuclear accumulation of baculovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Sustainable cutaneous gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Targeted gene delivery by tropism-modified adenoviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

A physicochemical approach for predicting the effectiveness of peptide-based gene delivery systems for use in plasmid-based gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte-derived macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Receptor-mediated gene transfer into macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Biochemical and functional analysis of an adenovirus-based ligand complex for gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Target cell-specific DNA transfer mediated by a chimeric multidomain protein. Novel non-viral gene delivery system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Controlling receptor/ligand trafficking: effects of cellular and molecular properties on endosomal sorting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

New class of polymers for the delivery of macromolecular therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Ligand-directed retroviral targeting of human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Receptor-mediated gene transfer to airway epithelial cells in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Retroviral display of functional binding domains fused to the amino terminus of influenza hemagglutinin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Retroviral stem cell gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

In or out? Regulating nuclear transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Tissue-specific targeting of retroviral vectors through ligand-receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Multicompartment, numerical model of cellular events in the pharmacokinetics of gene therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Oligonucleotide targeting to alveolar macrophages by mannose receptor-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Targeted infection of a retrovirus bearing a CD4-Env chimera into human cells expressing human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

CD5-mediated specific delivery of DNA to T lymphocytes: compartmentalization augmented by adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Targeted gene transfer to hepatocellular carcinoma cells in vitro using a novel monoclonal antibody-based gene delivery system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Intercellular delivery of functional p53 by the herpesvirus protein VP22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Specificity within the EGF family/ErbB receptor family signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Genetic engineering of proteins with cell membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Protein sorting by transport vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Generation of targeted retroviral vectors by using single-chain variable fragment: an approach to in vivo gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

The nuclear pore complex: from molecular architecture to functional dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Efficiency of targeted gene delivery of ligand-poly-L-lysine hybrids with different crosslinks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Cell-specific nuclear import of plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Delivery to cancer cells of antisense L-myc oligonucleotides incorporated in fusogenic, cationic-lipid-reconstituted influenza-virus envelopes (cationic virosomes).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Fusion of sequentially internalized vesicles in alveolar macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Quantitative analysis of protein synthesis inhibition and recovery in CRM107 immunotoxin-treated HeLa cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

General analysis of receptor-mediated viral attachment to cell surfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

A simple model to predict the effectiveness of molecules that block attachment of human rhinoviruses and other viruses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Nuclear import of plasmid DNA in digitonin-permeabilized cells requires both cytoplasmic factors and specific DNA sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Evidence for targeted gene delivery to Hep G2 hepatoma cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Cellular and molecular barriers to gene transfer by a cationic lipid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

In vitro gene delivery to hepatocytes with galactosylated polyethylenimine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Gene chemistry: functionally and conformationally intact fluorescent plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Receptor ligand-facilitated gene transfer: enhancement of liposome-mediated gene transfer and expression by transferrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Ferrying proteins to the other side

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Intracellular distribution of oligonucleotides delivered by cationic liposomes: light and electron microscopic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Analysis of intracellular receptor/ligand sorting in endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

Intracellular regulation of macromolecules using pH-sensitive liposomes and nuclear localization signal: qualitative and quantitative evaluation of intracellular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0290%2820001220%2970%3A6%3C593%3A%3AAID-BIT1%3E3.0.CO%3B2-N

10.1002/1097-0290(20001220)70:6<593::AID-BIT1>3.0.CO;2-N

21 January 2018

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

11064328