Loop-loop interaction of HIV-1 TAR RNA with N3'-->P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription (Q34075254)

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10 November 2019

title

Loop-loop interaction of HIV-1 TAR RNA with N3'-->P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription (English)

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10 November 2019

1

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10 November 2019

Jean-Jacques Toulmé

6

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10 November 2019

author name string

Andrey Arzumanov

2

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10 November 2019

Sergei Gryaznov

3

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10 November 2019

Michael J Gait

4

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10 November 2019

Carmelo Di Primo

5

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10 November 2019

language of work or name

English

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publication date

8 July 2002

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Proceedings of the National Academy of Sciences of the United States of America

10 November 2019

published in

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10 November 2019

volume

99

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10 November 2019

issue

15

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10 November 2019

page(s)

9709-9714

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Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.

10 November 2019

cites work

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Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction

5 July 2018

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Modulation of RNA function by oligonucleotides recognizing RNA structure

5 July 2018

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Inhibition of Tat-mediated transactivation of HIV-1 LTR transcription by polyamide nucleic acid targeted to TAR hairpin element

5 July 2018

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Aptamers as therapeutic and diagnostic agents

5 July 2018

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Is a closing "GA pair" a rule for stable loop-loop RNA complexes?

5 July 2018

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Targeting RNA with small molecules

5 July 2018

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In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1.

5 July 2018

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Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation

5 July 2018

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5 July 2018

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Multifaceted activities of the HIV-1 transactivator of transcription, Tat.

5 July 2018

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Dimerization of HIV-1 genomic RNA of subtypes A and B: RNA loop structure and magnesium binding

5 July 2018

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Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription

5 July 2018

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Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.

5 July 2018

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DNA aptamers selected against the HIV-1 trans-activation-responsive RNA element form RNA-DNA kissing complexes

5 July 2018

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Oligonucleotide inhibition of the interaction of HIV-1 Tat protein with the trans-activation responsive region (TAR) of HIV RNA.

5 July 2018

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The solution structure of an RNA loop-loop complex: the ColE1 inverted loop sequence

5 July 2018

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A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

5 July 2018

1 reference

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The structure of an RNA "kissing" hairpin complex of the HIV TAR hairpin loop and its complement

5 July 2018

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An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

5 July 2018

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Oligo-2'-fluoro-2'-deoxynucleotide N3'-->P5' phosphoramidates: synthesis and properties

5 July 2018

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Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex

5 July 2018

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The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein

5 July 2018

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HIV-1 tat trans-activation requires the loop sequence within tar.

5 July 2018

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Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

5 July 2018

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Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat

5 July 2018

1 reference

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Fragments of the HIV-1 Tat protein specifically bind TAR RNA.

5 July 2018

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N3'-->P5' Oligodeoxyribonucleotide Phosphoramidates: A New Method of Synthesis Based on a Phosphoramidite Amine-Exchange Reaction

5 July 2018

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High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region

21 January 2018

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Determinants of RNA hairpin loop-loop complex stability.

21 January 2018

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Measurement of intracellular (compartmental) pH by 31P NMR in Aspergillus niger

21 January 2018

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NMR solution structure of the N3' --> P5' phosphoramidate duplex d(CGCGAATTCGCG)2 by the iterative relaxation matrix approach

21 January 2018

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New candidates for true antisense

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1073/PNAS.122247199

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12105271%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

0 references

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10 November 2019

PubMed publication ID

12105271

1 reference