Small molecule alpha(v) integrin antagonists: novel anticancer agents (Q34074899)

30 July 2017

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title

Small molecule alpha(v) integrin antagonists: novel anticancer agents (English)

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30 July 2017

Kerr JS

1

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30 July 2017

Slee AM

series ordinal

2

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30 July 2017

Mousa SA

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

1 June 2000

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Expert Opinion on Investigational Drugs

30 July 2017

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30 July 2017

9

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30 July 2017

6

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30 July 2017

1271-1279

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Arg-Gly-Asp: a versatile cell recognition signal

30 July 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Integrins: versatility, modulation, and signaling in cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

A link between cyclin A expression and adhesion-dependent cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

The extracellular matrix as a cell survival factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Peptide ligands for integrin alpha v beta 3 selected from random phage display libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

RGD and other recognition sequences for integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Echistatin is a potent inhibitor of bone resorption in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

ArgGlyAsp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts*1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Role of the alpha v beta 3 integrin in human melanoma cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Tumour progression and metastatic behaviour in vivo correlates with integrin expression on melanocytic tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Role of V Integrins and Vitronectin in Human Melanoma Cell Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

The role of the integrin vitronectin receptor, alpha v beta 3 in melanoma metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Requirement of vascular integrin alpha v beta 3 for angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Basic FGF and TGF-beta differentially modulate integrin expression of human microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Expression of integrin alpha v beta 3 in small blood vessels of glioblastoma tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Confocal microscopic analysis of integrin expression on the microvasculature and its sprouts in the neonatal foreskin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Disintegrins: a family of integrin inhibitory proteins from viper venoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

In vitro and in vivo effects of a cyclic peptide with affinity for the alpha(nu)beta3 integrin in human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.6.1271

10.1517/13543784.9.6.1271

21 January 2018

Identifiers

DOI

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30 July 2017

1 reference