Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death (Q34072615)

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English	Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death	scientific article

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scholarly article

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Europe PubMed Central

30 July 2017

Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death (English)

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Europe PubMed Central

30 July 2017

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4 June 2020

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Pamela A G Clarke

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4 June 2020

Jignesh Parmar

3

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4 June 2020

Rong Hu

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4 June 2020

Jessica L Schwartz-Roberts

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4 June 2020

Mones Abu-Asab

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4 June 2020

Anni Wärri

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4 June 2020

William T Baumann

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4 June 2020

Robert Clarke

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23 May 2014

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30 July 2017

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4 June 2020

28

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4 June 2020

3891-3905

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4 June 2020

describes a project that uses

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Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139896

5 July 2018

Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139896

5 July 2018

Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139896

5 July 2018

Targeting GRP78 and antiestrogen resistance in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139896

5 July 2018

Nrf2-Keap1 antioxidant defense and cell survival signaling are upregulated by 17β-estradiol in homocysteine-treated dopaminergic SH-SY5Y cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139896

5 July 2018

Heat shock 70 kDa protein 5/glucose-regulated protein 78 "AMP"ing up autophagy

1 reference

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5 July 2018

CD47 deficiency confers cell and tissue radioprotection by activation of autophagy

1 reference

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5 July 2018

Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139896

5 July 2018

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress.

1 reference

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5 July 2018

Breast cancer statistics, 2011.

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5 July 2018

Autophagy and endocrine resistance in breast cancer

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5 July 2018

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

1 reference

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5 July 2018

Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response

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5 July 2018

PKR-dependent CHOP induction limits hyperoxia-induced lung injury.

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5 July 2018

Targeting ER stress induced apoptosis and inflammation in cancer.

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5 July 2018

Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation

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5 July 2018

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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5 July 2018

Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.

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5 July 2018

Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139896

5 July 2018

Activation and clinical significance of the unfolded protein response in breast cancer

1 reference

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5 July 2018

Regulation mechanisms and signaling pathways of autophagy

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5 July 2018

The role of X-box binding protein-1 in tumorigenicity.

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5 July 2018

Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells

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5 July 2018

Autophagy facilitates the progression of ERalpha-positive breast cancer cells to antiestrogen resistance

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139896

5 July 2018

A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance

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5 July 2018

Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization

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5 July 2018

Estradiol stimulates transcription of nuclear respiratory factor-1 and increases mitochondrial biogenesis.

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5 July 2018

Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.

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5 July 2018

Endocrine therapy resistance can be associated with high estrogen receptor alpha (ERalpha) expression and reduced ERalpha phosphorylation in breast cancer models.

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5 July 2018

NF-kappaB activation by reactive oxygen species: fifteen years later

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5 July 2018

Functional estrogen receptors in the mitochondria of breast cancer cells

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5 July 2018

Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer

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5 July 2018

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

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5 July 2018

Genome-wide identification of high-affinity estrogen response elements in human and mouse

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5 July 2018

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

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5 July 2018

Ligand-independent activation of estrogen receptor alpha by XBP-1

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5 July 2018

Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780).

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5 July 2018

Molecular and pharmacological aspects of antiestrogen resistance

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5 July 2018

Cellular and molecular pharmacology of antiestrogen action and resistance

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5 July 2018

MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen

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Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications.

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5 July 2018

Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-alpha

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28 October 2018

Identifiers

10.1096/FJ.13-247353

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4 June 2020

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Europe PubMed Central

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4 June 2020

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4 June 2020

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