Coexistence of two adamantane binding sites in the influenza A M2 ion channel (Q34068392)

30 July 2017

Coexistence of two adamantane binding sites in the influenza A M2 ion channel (English)

1 reference

30 July 2017

Matthew R Rosenberg

1

1 reference

PubMed ID

20643947

30 July 2017

Marco G Casarotto

series ordinal

2

1 reference

PubMed ID

20643947

30 July 2017

language of work or name

English

0 references

publication date

19 July 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

1 reference

30 July 2017

107

1 reference

30 July 2017

31

1 reference

30 July 2017

13866-13871

1 reference

Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Where does amantadine bind to the influenza virus M2 proton channel?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Designing inhibitors of M2 proton channel against H1N1 swine influenza virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Binding hot spots and amantadine orientation in the influenza a virus M2 proton channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Conformational heterogeneity of the M2 proton channel and a structural model for channel activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Mechanism of drug inhibition and drug resistance of influenza A M2 channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Structure of Amantadine-Bound M2 Transmembrane Peptide of Influenza A in Lipid Bilayers from Magic-Angle-Spinning Solid-State NMR: The Role of Ser31 in Amantadine Binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Structural basis for the function and inhibition of an influenza virus proton channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Structure and mechanism of the M2 proton channel of influenza A virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Solid-state NMR and MD simulations of the antiviral drug amantadine solubilized in DMPC bilayers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Proton transport behavior through the influenza A M2 channel: insights from molecular simulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

The chemical and dynamical influence of the anti-viral drug amantadine on the M2 proton channel transmembrane domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

The molecular basis of the specific anti-influenza action of amantadine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Molecular basis of resistance of influenza A viruses to amantadine.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Structural characteristics of the M2 protein of influenza A viruses: evidence that it forms a tetrameric channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Unpacking the incoming influenza virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

Influenza virus M2 protein has ion channel activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922235

ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE).

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002051107

Prolonged excretion of amantadine-resistant influenza a virus quasi species after cessation of antiviral therapy in an immunocompromised patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002051107

A novel method of resistance for influenza against a channel-blocking antiviral drug.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002051107

Conductance and amantadine binding of a pore formed by a lysine-flanked transmembrane domain of SARS coronavirus envelope protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002051107

Amantadine partition and localization in phospholipid membrane: a solution NMR study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002051107

Probing the mechanism of drug/lipid membrane interactions using Biacore

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002051107

Design and synthesis of bioactive 1,2-annulated adamantane derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002051107

Characterisation of the binding of cationic amphiphilic drugs to phospholipid bilayers using surface plasmon resonance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1002051107

21 January 2018

Identifiers

DOI

10.1073/PNAS.1002051107

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference

PubMed ID

20643947