Long term exendin-4 treatment reduces food intake and body weight and alters expression of brain homeostatic and reward markers (Q34068305)

30 July 2017

title

Long term exendin-4 treatment reduces food intake and body weight and alters expression of brain homeostatic and reward markers (English)

1 reference

30 July 2017

3

Zachary A Cordner

1 reference

30 July 2017

Yan Yang

1

1 reference

30 July 2017

Alexander A Moghadam

series ordinal

2

1 reference

30 July 2017

Nu-Chu Liang

series ordinal

4

1 reference

30 July 2017

Timothy H Moran

series ordinal

5

1 reference

30 July 2017

language of work or name

English

0 references

publication date

20 June 2014

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30 July 2017

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30 July 2017

volume

155

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30 July 2017

issue

9

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30 July 2017

page(s)

3473-3483

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Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of membrane-bound Akt.

30 July 2017

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1 reference

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High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats.

5 July 2018

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Nucleus accumbens GLP-1 receptors influence meal size and palatability.

5 July 2018

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Combination of obesity and high-fat feeding diminishes sensitivity to GLP-1R agonist exendin-4.

5 July 2018

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5 July 2018

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History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control study

5 July 2018

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AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling

5 July 2018

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Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes

5 July 2018

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Maternal high-fat diet during gestation or suckling differentially affects offspring leptin sensitivity and obesity

5 July 2018

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Additive feeding inhibitory and aversive effects of naltrexone and exendin-4 combinations

5 July 2018

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The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide

5 July 2018

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5 July 2018

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GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake

5 July 2018

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Role of the hypothalamus in the neuroendocrine regulation of body weight and composition during energy deficit

5 July 2018

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Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake

5 July 2018

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Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide

5 July 2018

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Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice

5 July 2018

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Peripheral ghrelin stimulates feeding behavior and positive energy balance in a sciurid hibernator

5 July 2018

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An overview on how components of the melanocortin system respond to different high energy diets

5 July 2018

1 reference

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Reward, dopamine and the control of food intake: implications for obesity

5 July 2018

1 reference

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Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long-term exposure to palatable food and differs depending on diet-induced obesity phenotype in rats

5 July 2018

1 reference

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Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

5 July 2018

1 reference

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Dose combinations of exendin-4 and salmon calcitonin produce additive and synergistic reductions in food intake in nonhuman primates

5 July 2018

1 reference

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Diabetes type II: a risk factor for depression-Parkinson-Alzheimer?

5 July 2018

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Sensitivity to the satiating effects of exendin 4 is decreased in obesity-prone Osborne-Mendel rats compared to obesity-resistant S5B/Pl rats

5 July 2018

1 reference

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Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation

5 July 2018

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Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study

5 July 2018

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Exenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus

5 July 2018

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Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward

5 July 2018

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Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression

5 July 2018

1 reference

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Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Glucagon-like peptide (GLP-1) is involved in the central modulation of fecal output in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Alteration of sweet taste in high-fat diet induced obese rats after 4 weeks treatment with exenatide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Glucagon-like peptide-1 agonist exendin-4 leads to reduction of weight and caloric intake in a rat model of hypothalamic obesity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Dopamine and food reward: effects of acute tyrosine/phenylalanine depletion on appetite

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Brain activation following peripheral administration of the GLP-1 receptor agonist exendin-4.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Exenatide therapy in insulin-treated type 2 diabetes and obesity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Insulin, glucose, and pancreatic polypeptide responses to a test meal in restricting type anorexia nervosa before and after weight restoration

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Obesity: the new worldwide epidemic threat to general health and our complete lack of effective treatment

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Hypothalamic gene expression in long-term fasted rats: relationship with body fat.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138563

GLP-1 analogs: satiety without malaise?

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24949661

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pylorectomy reduces the satiety action of cholecystokinin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24949661

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1210/EN.2014-1052

1 reference

30 July 2017

1 reference

30 July 2017

1 reference