A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo (Q34068238)

30 July 2017

A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo (English)

1 reference

30 July 2017

Edward M Sellers

4

0 references

Rachel F Tyndale

series ordinal

5

object named as

Rachel F Tyndale

1 reference

30 July 2017

2

Jasjit S Ahluwalia

1 reference

30 July 2017

Nael Al Koudsi

1

1 reference

30 July 2017

Shih-Ku Lin

series ordinal

3

1 reference

30 July 2017

language of work or name

1 reference

14 April 2009

1 reference

The Pharmacogenomics Journal

30 July 2017

1 reference

30 July 2017

9

1 reference

30 July 2017

4

1 reference

30 July 2017

274-282

1 reference

https://scigraph.springernature.com/pub.10.1038/tpj.2009.11

30 July 2017

0 references

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A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent

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Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism.

5 July 2018

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Female sex and oral contraceptive use accelerate nicotine metabolism

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Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

5 July 2018

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Pharmacogenetics: inherited variation in amino acid sequence and altered protein quantity

5 July 2018

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A nicotine C-oxidase gene (CYP2A6) polymorphism important for promoter activity

5 July 2018

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Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism

5 July 2018

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Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population

5 July 2018

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Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19

5 July 2018

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Structural function of residue-209 in coumarin 7-hydroxylase (P450coh). Enzyme-kinetic studies and site-directed mutagenesis

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Metabolism of nicotine to cotinine studied by a dual stable isotope method.

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Limitation of cigarette consumption by CYP2A6*4, *7 and *9 polymorphisms

21 January 2018

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Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

21 January 2018

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Toward personalized therapy for smoking cessation: a randomized placebo-controlled trial of bupropion.

21 January 2018

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Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity

21 January 2018

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Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted

21 January 2018

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Within-subject variation of the salivary 3HC/COT ratio in regular daily smokers: prospects for estimating CYP2A6 enzyme activity in large-scale surveys of nicotine metabolic rate.

21 January 2018

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CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.

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Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.

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Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

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An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles

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Whole deletion of CYP2A6 gene (CYP2A6AST;4C) and smoking behavior

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Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics

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Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation

21 January 2018

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Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression

21 January 2018

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Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy

21 January 2018

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Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers

21 January 2018

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The effects of nicotine gum and counseling among African American light smokers: a 2 x 2 factorial design

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Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking.

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Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5.

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CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability.

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Lack of association between smoking and CYP2A6 gene polymorphisms in A Japanese population.

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A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

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In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais

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A novel single nucleotide polymorphism altering stability and activity of CYP2a6

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Role of human cytochrome P4502A6 in C-oxidation of nicotine

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Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity

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Determinants of the rate of nicotine metabolism and effects on smoking behavior

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Identifiers

DOI

10.1038/TPJ.2009.11

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference