Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik (Q34056627)

30 July 2017

title

Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik (English)

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30 July 2017

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8

Robert Z Orlowski

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30 July 2017

Shuang Chen

1

1 reference

30 July 2017

Liang Zhou

2

1 reference

30 July 2017

Yu Zhang

3

1 reference

30 July 2017

Yun Leng

4

1 reference

30 July 2017

Xin-Yan Pei

5

1 reference

30 July 2017

Hui Lin

6

1 reference

30 July 2017

Richard Jones

7

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30 July 2017

Yun Dai

9

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30 July 2017

Steven Grant

10

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30 July 2017

language of work or name

English

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publication date

7 July 2014

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Molecular and Cellular Biology

30 July 2017

published in

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30 July 2017

volume

34

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30 July 2017

issue

18

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30 July 2017

page(s)

3435-3449

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K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells

30 July 2017

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5 July 2018

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Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

5 July 2018

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Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming

5 July 2018

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A master conductor for aggregate clearance by autophagy

5 July 2018

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Selective autophagy in cancer development and therapy

5 July 2018

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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

5 July 2018

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Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

5 July 2018

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5 July 2018

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5 July 2018

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HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.

5 July 2018

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Autophagy suppresses tumorigenesis through elimination of p62

5 July 2018

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Effect of autophagy on multiple myeloma cell viability

5 July 2018

1 reference

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A role for ubiquitin in selective autophagy

5 July 2018

1 reference

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A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation

5 July 2018

1 reference

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Bcl-2 family members: dual regulators of apoptosis and autophagy

5 July 2018

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Excess peroxisomes are degraded by autophagic machinery in mammals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Subversion of cellular autophagosomal machinery by RNA viruses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Inhibition of macroautophagy triggers apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Induction of autophagy and inhibition of tumorigenesis by beclin 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135623

Selective autophagy: ubiquitin-mediated recognition and beyond

28 October 2018

1 reference

12 December 2020

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

1 reference

12 December 2020

Autophagy dysfunction and ubiquitin-positive protein aggregates in Dictyostelium cells lacking Vmp1

1 reference

12 December 2020

Selective turnover of p62/A170/SQSTM1 by autophagy

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.01383-13

1 reference

30 July 2017

1 reference

30 July 2017

1 reference