The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. (Q34041946)

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3 February 2020

title

The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation (English)

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4

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Gustavo J. Martinez

6

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3 February 2020

author name string

Roza I Nurieva

1

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3 February 2020

Shuling Zheng

2

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Wei Jin

3

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3 February 2020

Yongliang Zhang

5

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Joseph M Reynolds

7

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3 February 2020

Sung-Ling Wang

8

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Xin Lin

9

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Shao-Cong Sun

10

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Guillermina Lozano

11

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Chen Dong

12

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language of work or name

English

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publication date

20 May 2010

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volume

32

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issue

5

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3 February 2020

page(s)

670-680

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E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance

3 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

5 July 2018

1 reference

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

5 July 2018

1 reference

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GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus

5 July 2018

1 reference

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A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Regulation of T cell activation and tolerance by PDL2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

T-cell tolerance or function is determined by combinatorial costimulatory signals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Immunity by ubiquitylation: a reversible process of modification

5 July 2018

1 reference

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Calcium-dependent activation of interleukin-21 gene expression in T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

E3 ligases in T cell anergy--turning immune responses into tolerance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915546

Real-time polymerase chain reaction analysis reveals an evolution of cytokine mRNA production in allograft acceptor mice

5 July 2018

1 reference

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Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice

5 July 2018

1 reference

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28 October 2018

1 reference

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c-Maf and JunB mediation of Th2 differentiation induced by the type 2 G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide

28 October 2018

1 reference

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c-Rel is required for chromatin remodeling across the IL-2 gene promoter

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20493730

12 December 2020

inferred from PubMed ID database lookup

A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20493730

12 December 2020

inferred from PubMed ID database lookup

Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20493730

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.IMMUNI.2010.05.002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20493730%20AND%20SRC:MED&resulttype=core&format=json

release_e4wmmzme7jhmjczz246eebp3sa

3 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/e4wmmzme7jhmjczz246eebp3sa

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20493730%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

20493730

1 reference