Inhibition of protein kinase Cbeta does not improve endothelial function in type 2 diabetes (Q34031989)

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1 February 2020

title

Inhibition of protein kinase Cbeta does not improve endothelial function in type 2 diabetes (English)

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1 February 2020

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1 February 2020

Allison B Goldfine

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1 February 2020

author name string

Alison Goldin

3

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1 February 2020

Adnan Prsic

4

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1 February 2020

Sora Kim

5

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1 February 2020

Mark A Creager

6

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language of work or name

English

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publication date

5 May 2010

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The Journal of Clinical Endocrinology and Metabolism

1 February 2020

published in

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1 February 2020

volume

95

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1 February 2020

issue

8

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1 February 2020

page(s)

3783-3787

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Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus

1 February 2020

cites work

1 reference

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Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial

5 July 2018

1 reference

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Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

Diabetes and atherosclerosis: epidemiology, pathophysiology, and management

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

The extended protein kinase C superfamily

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy

5 July 2018

1 reference

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The effect of ruboxistaurin on nephropathy in type 2 diabetes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

Apolipoprotein e4 allele and endothelium-dependent arterial dilation in Type 2 diabetes mellitus without angiopathy

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913029

Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance

29 October 2018

1 reference

12 December 2020

Impact of type 2 diabetes mellitus on aortic elastic properties in normotensive diabetes: Doppler tissue imaging study

1 reference

12 December 2020

Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus

1 reference

12 December 2020

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

1 reference

12 December 2020

Protein kinase betaII in Zucker obese rats compromises oxygen and flow-mediated regulation of nitric oxide formation

1 reference

12 December 2020

Inhibition of protein kinase Cbeta protects against diabetes-induced impairment in arachidonic acid dilation of small coronary arteries

1 reference

12 December 2020

Identifiers

DOI

10.1210/JC.2010-0286

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1 February 2020

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1 February 2020

PubMed publication ID

20444914

1 reference