Notch: the past, the present, and the future (Q34023784)

30 July 2017

Notch: the past, the present, and the future (English)

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Spiros Artavanis-Tsakonas

30 July 2017

series ordinal

1

object named as

Spyros Artavanis-Tsakonas

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30 July 2017

Marc A T Muskavitch

2

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30 July 2017

1 January 2010

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Current Topics in Developmental Biology

30 July 2017

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30 July 2017

92

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30 July 2017

1-29

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CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch signaling: cell fate control and signal integration in development

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

An overview of the Notch signalling pathway

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch signalling: a simple pathway becomes complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch is required for successive cell decisions in the developing Drosophila retina.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Intestinal stem cells in mammals and Drosophila

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Xotch, the Xenopus homolog of Drosophila notch

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The Analysis of a Case of Continuous Variation in Drosophila by a Study of Its Linkage Relations

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Signaling pathways in cancer and embryonic stem cells

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The suppressor of hairless protein participates in notch receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Endocytic regulation of Notch signaling

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch signals control the fate of immature progenitor cells in the intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch signalling and haematopoietic stem cell formation during embryogenesis

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

A role for Abl in Notch signaling.

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The molecular logic of Notch signaling--a structural and biochemical perspective.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Correlation of the physical and genetic maps in the lin-12 region of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The lin-12 locus specifies cell fates in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch signaling and inherited disease syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The molecular genetics of the Notch locus in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Wnt/Notch signalling and information processing during development.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The choice of cell fate in the epidermis of Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Nodal points and complexity of Notch-Ras signal integration

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Crossing paths with Notch in the hyper-network

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https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Signalling downstream of activated mammalian Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The Notch locus of Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The canonical Notch signaling pathway: unfolding the activation mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Direct response to Notch activation: signaling crosstalk and incoherent logic.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Jagged: a mammalian ligand that activates Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch signalling in vertebrate neural development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Down-regulation of Delta by proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Direct inhibition of the NOTCH transcription factor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch1 functions as a tumor suppressor in mouse skin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Mutations affecting segment number and polarity in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Secretion of the Notch-1 Abeta-like peptide during Notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

shibire, a neurogenic mutant of Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The glp-1 locus and cellular interactions in early C. elegans embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Processing of the notch ligand delta by the metalloprotease Kuzbanian

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Calcium binding to tandem repeats of EGF-like modules. Expression and characterization of the EGF-like modules of human Notch-1 implicated in receptor-ligand interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Ligand-independent traffic of Notch buffers activated Armadillo in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Cell autonomy of lin-12 function in a cell fate decision in C. elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Jagged2: a serrate-like gene expressed during rat embryogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Lateral inhibition during vulval induction in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The action of the notch locus in Drosophila melanogaster. I. Effects of the notch8 deficiency on mitochondrial enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Analysis of a Gene in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Therapeutic antibody targeting of individual Notch receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992001-2

7 January 2021

10.1016/S0070-2153(10)92001-2

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

20816391