No grip, no growth: the conceptual basis of excessive proteolysis in the treatment of cancer (Q34013819)

30 July 2017

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title

No grip, no growth: the conceptual basis of excessive proteolysis in the treatment of cancer (English)

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30 July 2017

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Reijerkerk A

1

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PubMed ID

10959055

30 July 2017

Voest EE

series ordinal

2

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PubMed ID

10959055

30 July 2017

Gebbink MF

series ordinal

3

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30 July 2017

1 August 2000

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European Journal of Cancer

30 July 2017

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30 July 2017

36

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30 July 2017

13 Spec No

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30 July 2017

1695-1705

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Fighting cancer by attacking its blood supply

30 July 2017

1 reference

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7 January 2021

Antiangiogenic activity of the cleaved conformation of the serpin antithrombin

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7 January 2021

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

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7 January 2021

The hemostatic system as a regulator of angiogenesis

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7 January 2021

Fibrin as a component of the tumor stroma: origins and biological significance

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7 January 2021

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

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7 January 2021

Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: conversion of prothrombin to thrombin results in progelatinase A activation and cell proliferation

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7 January 2021

Tumor angiogenesis and tissue factor

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7 January 2021

Tissue factor in cancer angiogenesis and metastasis

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7 January 2021

The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development.

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7 January 2021

Vitronectin decreases microvascular endothelial cell apoptosis

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis

1 reference

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7 January 2021

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Role of specific membrane receptors in urokinase-dependent migration of human keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Urokinase induces receptor mediated brain tumor cell migration and invasion.

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

The presence of plasmin receptors on three mammary carcinoma MCF-7 sublines

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Binding of tissue plasminogen activator to cultured human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

The role of an enolase-related molecule in plasminogen binding to cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Role of cell-surface lysines in plasminogen binding to cells: identification of .alpha.-enolase as a candidate plasminogen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Binding of human plasminogen to basement-membrane (type IV) collagen

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Initial plasmin-degradation of fibrin as the basis of a positive feed-back mechanism in fibrinolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Molecular assembly of plasminogen and tissue-type plasminogen activator on an evolving fibrin surface

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Characterization of the binding of plasminogen to fibrin surfaces: the role of carboxy-terminal lysines.

1 reference

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7 January 2021

A study of the mechanism of inhibition of fibrinolysis by activated thrombin-activable fibrinolysis inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

An arginine specific carboxypeptidase generated in blood during coagulation or inflammation which is unrelated to carboxypeptidase N or its subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Activation and characterization of procarboxypeptidase B from human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Thrombomodulin-dependent anticoagulant activity is regulated by vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Inhibition of establishment of primary and micrometastatic tumors by a urokinase plasminogen activator receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Blockage of urokinase receptor reduces in vitro the motility and the deformability of endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Blockage of the urokinase receptor on the cell surface: construction and characterization of a hybrid protein consisting of the N-terminal fragment of human urokinase and human albumin

1 reference

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7 January 2021

Cooperative effect of TNFalpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity

1 reference

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7 January 2021

The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice

1 reference

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7 January 2021

Antibodies to plasminogen activator inhibit human tumor metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1 reference

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7 January 2021

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Effect of aprotinin on metastasis of Lewis lung tumor in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Effect of tranexamic acid on progress of experimental tumours and on DNA-synthesis

1 reference

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7 January 2021

Antifibrinolytic therapy of experimentally grown malignant brain tumors

1 reference

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7 January 2021

Tranexamic acid for the treatment of advanced ovarian carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Adjuvant effects of tranexamic acid to chemotherapy in ovarian cancer patients with large amount of ascites

1 reference

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7 January 2021

Treatment of advanced breast cancer with chemotherapeutics and inhibition of coagulation and fibrinolysis

1 reference

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7 January 2021

Effect of tranexamic acid on choroidal melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Treatment of advanced ovarian cancer with fibrinolytic inhibitor (tranexamic acid)

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Aminocaproic acid (AMICAR) in advanced colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Angiostatin induces and sustains dormancy of human primary tumors in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Suppression of tumor growth with recombinant murine angiostatin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Endostatin induces endothelial cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Inhibition of pulmonary tumor seeding by antiplatelet and fibrinolytic therapy in an animal experimental model

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Streptokinase inhibits pulmonary tumor seeding in an animal experimental model

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Visualization of the plasmin receptor on sections of human mammary carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Human Co115 colon carcinoma cells potentiate the degradation of laminin mediated by tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Plasma and recombinant thrombin-activable fibrinolysis inhibitor (TAFI) and activated TAFI compared with respect to glycosylation, thrombin/thrombomodulin-dependent activation, thermal stability, and enzymatic properties

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

The implications of angiogenesis for the biology and therapy of cancer metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3)

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Generation of Angiostatin by Reduction and Proteolysis of Plasmin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Angiostatin binds ATP synthase on the surface of human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Limited plasmin proteolysis of vitronectin. Characterization of the adhesion protein as morpho-regulatory and angiostatin-binding factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Effects of kringles derived from human plasminogen on fibrinolysis in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Hepatocytes as a source of collagen type XVIII endostatin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Endostatin binds to blood vessels in situ independent of heparan sulfate and does not compete for fibroblast growth factor-2 binding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Isolation and characterization of the circulating form of human endostatin.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Mechanism of action of angiostatic steroids: suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to lung and liver in an athymic mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

The urokinase-type plasminogen activator system in cancer metastasis: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Significance of fibrin formation and dissolution in the pathogenesis and treatment of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Fibrinogen degradation product fragment D induces endothelial cell detachment by activation of cell-mediated fibrinolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Plasmin abrogates alpha v beta 5-mediated adhesion of a human keratinocyte cell line (HaCaT) to vitronectin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Plasmin modulators, aprotinin and anti-catalytic plasmin antibody, efficiently inhibit destruction of bovine vascular endothelial cells by choriocarcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Effect of tumor necrosis factor on the human fibrinolytic system

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Plasminogen activator and its inhibitor in cancer patients treated with tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Generation of macrophage migration inhibitory activity by plasminogen activators

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Involvement of platelets in tumour angiogenesis?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Human prothrombin fragment 1 and 2 inhibit bFGF-induced BCE cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

Maspin is an angiogenesis inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900157-X

7 January 2021

10.1016/S0959-8049(00)00157-X

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10959055