High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity (Q34001563)

30 July 2017

title

High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity (English)

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30 July 2017

12

Andreas Schatzlein

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30 July 2017

Sital M Patel

1

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30 July 2017

Maria de la Fuente

2

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30 July 2017

Song Ke

3

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30 July 2017

Andreia M R Guimarães

4

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Adeola O Oliyide

5

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Xiaoyun Ji

6

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Paul Stapleton

7

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Anne Osbourn

8

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Yi Pan

9

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Dianna J Bowles

10

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30 July 2017

Benjamin G Davis

11

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Min Yang

13

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30 July 2017

language of work or name

English

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publication date

24 August 2011

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30 July 2017

number of pages

3

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based on heuristic

inferred from page(s)

published in

Chemical Communications

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volume

47

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issue

38

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page(s)

10569-10571

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Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase

30 July 2017

cites work

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Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells

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Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines

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Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis.

21 January 2018

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Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents

21 January 2018

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The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity

21 January 2018

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Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.

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Colchicine glycorandomization influences cytotoxicity and mechanism of action

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Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

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Antibiotic optimization via in vitro glycorandomization

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Probing the aglycon promiscuity of an engineered glycosyltransferase

21 January 2018

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21 January 2018

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High-throughput mass-spectrometry monitoring for multisubstrate enzymes: determining the kinetic parameters and catalytic activities of glycosyltransferases.

21 January 2018

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Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification

21 January 2018

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Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.

21 January 2018

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Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization

21 January 2018

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KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells

21 January 2018

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Targeting the dynamic HSP90 complex in cancer

21 January 2018

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Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket

21 January 2018

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Probing the Breadth of Macrolide Glycosyltransferases: In Vitro Remodeling of a Polyketide Antibiotic Creates Active Bacterial Uptake and Enhances Potency

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/C1CC13552J

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30 July 2017

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