Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide (Q34000287)

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4 February 2020

title

Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide (English)

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4 February 2020

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Renske D. Steenbergen

6

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4 February 2020

Berend J Slotman

9

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4 February 2020

Wendy F van der Meide

3

object named as

W F van der Meide

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4 February 2020

author name string

K A van Nifterik

1

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4 February 2020

J van den Berg

2

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4 February 2020

N Ameziane

4

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4 February 2020

L E Wedekind

5

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4 February 2020

S Leenstra

7

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4 February 2020

M V M Lafleur

8

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4 February 2020

L J A Stalpers

10

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4 February 2020

P Sminia

11

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4 February 2020

language of work or name

English

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publication date

1 June 2010

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British Journal of Cancer

4 February 2020

published in

1 reference

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4 February 2020

volume

103

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4 February 2020

issue

1

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4 February 2020

page(s)

29-35

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https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605712

4 February 2020

exact match

0 references

cites work

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MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma.

5 July 2018

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5 July 2018

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MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas

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Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide

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O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

5 July 2018

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Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences

5 July 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

5 July 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

5 July 2018

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Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin.

5 July 2018

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Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene

5 July 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

5 July 2018

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Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase

5 July 2018

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5 July 2018

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Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas

28 July 2018

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Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach.

21 January 2018

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Quantitative GSTP1 methylation clearly distinguishes benign prostatic tissue and limited prostate adenocarcinoma

21 January 2018

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21 January 2018

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

29 October 2018

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Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20517307

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

MGMT immunohistochemical expression and promoter methylation in human glioblastoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20517307

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJC.6605712

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20517307%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20517307%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference