Recent application of analytical methods to phase I and phase II drugs development: a review (Q33997398)

30 July 2017

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title

Recent application of analytical methods to phase I and phase II drugs development: a review (English)

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30 July 2017

Marcello Locatelli

1

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30 July 2017

Luciana Governatori

2

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30 July 2017

Giuseppe Carlucci

3

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30 July 2017

Salvatore Genovese

4

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30 July 2017

Adriano Mollica

5

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30 July 2017

Francesco Epifano

6

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30 July 2017

19 August 2011

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Biomedical Chromatography

30 July 2017

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30 July 2017

26

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30 July 2017

3

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30 July 2017

283-300

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High throughput solubility measurement in drug discovery and development

30 July 2017

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Capillary electrophoresis for forensic drug analysis: A review

21 January 2018

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The estradiol pharmacophore: ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site

21 January 2018

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Development of validated stability-indicating assay methods--critical review

21 January 2018

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Drug discovery from medicinal plants.

21 January 2018

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Peptide drugs to target G protein-coupled receptors

21 January 2018

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Inclusion of women in clinical trials

21 January 2018

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Importance of single or blended polymer types for controlled in vitro release and plasma levels of a somatostatin analogue entrapped in PLA/PLGA microspheres.

21 January 2018

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A stability-indicating HPLC method for medroxyprogesterone acetate in bulk drug and injection formulation

21 January 2018

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Natural products to drugs: natural product-derived compounds in clinical trials

21 January 2018

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Frontal affinity chromatography in characterizing immobilized receptors

21 January 2018

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Protein structure determination from NMR chemical shifts

21 January 2018

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Preferred conformations of endogenous cannabinoid ligand anandamide

21 January 2018

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Purification of recombinant growth hormone by clear native gels for conformational analyses: preservation of conformation and receptor binding

21 January 2018

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Integration of virtual screening into the drug discovery process

21 January 2018

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Effect of highly fluorinated amino acids on protein stability at a solvent-exposed position on an internal strand of protein G B1 domain

21 January 2018

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Advances in capillary electrophoresis.

21 January 2018

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Recent developments in solid-phase microextraction coatings and related techniques

21 January 2018

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Recent advances in QSAR and their applications in predicting the activities of chemical molecules, peptides and proteins for drug design

21 January 2018

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In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling

21 January 2018

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Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids

21 January 2018

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Determination of the dissociation constants of the cephalosporins cefepime and cefpirome using UV spectrometry and pH potentiometry

21 January 2018

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Bioanalysis of recombinant proteins and antibodies by mass spectrometry

21 January 2018

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Phase I and pharmacokinetic study of aplidine, a new marine cyclodepsipeptide in patients with advanced malignancies.

21 January 2018

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Electrospray ionization for mass spectrometry of large biomolecules

21 January 2018

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Determination of local anaesthetics and their impurities in pharmaceutical preparations using HPLC method with amperometric detection

21 January 2018

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Emerging methods for the rapid determination of enantiomeric excess

21 January 2018

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Investigation on the photochemical stability of lercanidipine and its determination in tablets by HPLC-UV and LC-ESI-MS/MS.

21 January 2018

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Biomedical and biochemical applications of liquid chromatography-mass spectrometry

21 January 2018

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Pharmaceutical and related drugs

21 January 2018

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Advances in protein complex analysis using mass spectrometry

21 January 2018

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Determination of pK(a) values of some antihypertensive drugs by liquid chromatography and simultaneous assay of lercanidipine and enalapril in their binary mixtures

21 January 2018

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Chromatographic and electrophoretic studies of protein binding to chiral solutes

21 January 2018

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Development and validation of a stability indicating capillary electrophoresis method for the determination of metformin hydrochloride in tablets.

21 January 2018

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Capillary zone electrophoresis method for the determination of famotidine and related impurities in pharmaceuticals.

21 January 2018

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Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution

21 January 2018

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High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites

21 January 2018

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Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection

21 January 2018

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Simultaneous determination of barbiturates in human biological fluids by direct immersion solid-phase microextraction and gas chromatography-mass spectrometry.

21 January 2018

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Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: absence of toxicity due to saturating absorption.

21 January 2018

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Determination of theophylline and its metabolites in biological samples by liquid chromatography-mass spectrometry.

21 January 2018

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Recent developments in CE and CEC of peptides

21 January 2018

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Recent advances in SPME techniques in biomedical analysis

21 January 2018

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HPTLC method for determination of nevirapine in pharmaceutical dosage form

21 January 2018

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Rapid analysis of the interactions between drugs and human serum albumin (HSA) using high-performance affinity chromatography (HPAC).

21 January 2018

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Principles and applications of LC-MS in new drug discovery

21 January 2018

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Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies.

21 January 2018

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Impurity profile study of repaglinide

21 January 2018

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Metabolism of antimalarial sesquiterpene lactones.

21 January 2018

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Theory and applications of NMR-based screening in pharmaceutical research

21 January 2018

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Current developments in LC-MS for pharmaceutical analysis

21 January 2018

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Anthraquinones: analytical techniques as a novel tool to investigate on the triggering of biological targets

21 January 2018

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Relation between retention factors of immunosuppressive drugs in microemulsion electrokinetic chromatography with biosurfactants and octanol-water partition coefficients.

21 January 2018

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Methods to determine pharmacokinetic profiles of therapeutic proteins

21 January 2018

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Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins

21 January 2018

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Coupling liquid chromatography to Orbitrap mass spectrometry

21 January 2018

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Determination of topiramate in human plasma by capillary electrophoresis with indirect UV detection

21 January 2018

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Stability of protein pharmaceuticals: an update

21 January 2018

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Characterization of antihistamine-human serum protein interactions by capillary electrophoresis

21 January 2018

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Multi-analyte procedures for screening for and quantification of drugs in blood, plasma, or serum by liquid chromatography-single stage or tandem mass spectrometry (LC-MS or LC-MS/MS) relevant to clinical and forensic toxicology

21 January 2018

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Lipophilicity of vinpocetine and related compounds characterized by reversed-phase thin-layer chromatography

21 January 2018

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NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors

21 January 2018

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Solubility, dissolution rate and phase transition studies of ranitidine hydrochloride tautomeric forms

21 January 2018

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Mass spectrometric immunoassay

21 January 2018

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High throughput therapeutic drug monitoring of clozapine and metabolites in serum by on-line coupling of solid phase extraction with liquid chromatography-mass spectrometry

21 January 2018

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The aqueous stability of bupropion

21 January 2018

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Determination of dissociation constants of labile drug compounds by capillary electrophoresis

21 January 2018

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High-throughput multiplexed capillary electrophoresis in drug discovery

21 January 2018

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Development and validation of an EI-GC-MS method for the determination of benzodiazepine drugs and their metabolites in blood: applications in clinical and forensic toxicology

21 January 2018

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Drug delivery: an odyssey of 100 years

21 January 2018

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Increasing participation of women in early phase clinical trials approved by the FDA.

21 January 2018

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Delivery of therapeutic proteins

21 January 2018

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Liquid chromatography-positive ion electrospray mass spectrometry method for the quantification of citalopram in human plasma

21 January 2018

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Separation methods for estimating octanol-water partition coefficients

21 January 2018

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Determination of acid dissociation constants by capillary electrophoresis

21 January 2018

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Determination of nimodipine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and pharmacokinetic application

21 January 2018

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Stability indicating methods for the determination of loratadine in the presence of its degradation product

21 January 2018

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Trends in development and approval times for new therapeutics in the United States

21 January 2018

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Enhancing adherence in clinical research

21 January 2018

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Advances in the theory and application of MEEKC.

21 January 2018

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Simultaneous determination of quinine and chloroquine anti-malarial agents in pharmaceuticals and biological fluids by HPLC and fluorescence detection

21 January 2018

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Measurement of drug-protein dissociation rates by high-performance affinity chromatography and peak profiling

21 January 2018

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From drug target to leads--sketching a physicochemical pathway for lead molecule design in silico

21 January 2018

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Plasma protein binding study of oxybutynin by high-performance frontal analysis

21 January 2018

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Directly coupled HPLC-NMR and HPLC-MS approaches for the rapid characterisation of drug metabolites in urine: application to the human metabolism of naproxen

21 January 2018

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Capillary electrophoresis with UV detection and mass spectrometry in method development for profiling metabolites of steroid hormone metabolism

21 January 2018

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Capillary electrophoresis of diuretics and probenecid in methanol

21 January 2018

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Effects of glycosylation on the stability of protein pharmaceuticals

21 January 2018

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Analysis of lidocaine interactions with serum proteins using high-performance affinity chromatography

21 January 2018

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Enantiomeric determination of amlodipine in human plasma by liquid chromatography coupled to tandem mass spectrometry

21 January 2018

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Recent advances of capillary electrophoresis in pharmaceutical analysis

21 January 2018

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Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products

21 January 2018

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Estimation of binding constants by capillary electrophoresis

21 January 2018

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Pharmacokinetic aspects of biotechnology products

21 January 2018

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Application of solid-phase microextraction in the investigation of protein binding of pharmaceuticals

21 January 2018

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Development of recombinant-based mass spectrometric immunoassay with application to resistin expression profiling

21 January 2018

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Unconventional natural sources for future drug discovery

21 January 2018

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Solid-phase microextraction in biomedical analysis

21 January 2018

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Solid-phase microextraction: a powerful sample preparation tool prior to mass spectrometric analysis

21 January 2018

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Drug-protein binding: a critical review of analytical tools

21 January 2018

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Biopharmaceuticals: recent approvals and likely directions

21 January 2018

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NMR of drugs and ligands bound to membrane receptors

21 January 2018

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Determination of dissociation constants of pharmacologically active xanthones by capillary zone electrophoresis with diode array detection.

21 January 2018

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Stereoselective analysis of carvedilol in human plasma using HPLC/MS/MS after chiral derivatization

21 January 2018

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Recent development in application of high performance liquid chromatography-tandem mass spectrometry in therapeutic drug monitoring of immunosuppressants.

21 January 2018

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Drug discovery beyond the 'rule-of-five'.

21 January 2018

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Protein binding study of clozapine by capillary electrophoresis in the frontal analysis mode

21 January 2018

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Optimization of the Near-Infrared Fluorescence Labeling for In Vivo Monitoring of a Protein Drug Distribution in Animal Model

21 January 2018

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Detection of recombinant bovine somatotropin in milk and effect of industrial processes on its stability

21 January 2018

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Applications of NMR in drug discovery

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BMC.1674

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30 July 2017

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