Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation (Q33993867)

30 July 2017

title

Inactivation of p16 in human mammary epithelial cells by CpG island methylation (English)

1 reference

30 July 2017

Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation (English)

1 reference

https://api.crossref.org/works/10.1128/MCB.18.4.1793

15 December 2024

1 reference

4

D A Galloway

1 reference

30 July 2017

S. A. Foster

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9528751

15 December 2024

D. J. Wong

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9528751

15 December 2024

M. T. Barrett

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9528751

15 December 2024

D. A. Galloway

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9528751

15 December 2024

publication date

1 April 1998

1 reference

30 July 2017

April 1998

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9528751

https://europepmc.org/articles/pmc121409?pdf=render

15 December 2024

language of work or name

English

0 references

work available at URL

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9528751

http://mcb.asm.org/cgi/content/abstract/18/4/1793

15 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9528751

https://europepmc.org/articles/PMC121409

15 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9528751

https://europepmc.org/articles/PMC121409?pdf=render

15 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9528751

https://journals.asm.org/doi/pdf/10.1128/MCB.18.4.1793

15 December 2024

1 reference

https://api.crossref.org/works/10.1128/MCB.18.4.1793

https://www.tandfonline.com/doi/pdf/10.1128/MCB.18.4.1793

15 December 2024

1 reference

https://api.crossref.org/works/10.1128/MCB.18.4.1793

Molecular and Cellular Biology

15 December 2024

published in

1 reference

30 July 2017

volume

18

1 reference

30 July 2017

issue

4

1 reference

30 July 2017

page(s)

1793-1801

1 reference

describes a project that uses

30 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC121409/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

5 July 2018

1 reference

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Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein

5 July 2018

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5 July 2018

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Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation.

5 July 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

5 July 2018

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Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells

5 July 2018

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5 July 2018

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Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit

5 July 2018

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Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

5 July 2018

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Human papillomavirus type 16 E7 alleviates a proliferation block in early passage human mammary epithelial cells

5 July 2018

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

5 July 2018

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Redundant cyclin overexpression and gene amplification in breast cancer cells

5 July 2018

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E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts

5 July 2018

1 reference

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Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

5 July 2018

1 reference

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Alteration of the DCC tumor-suppressor gene in tumorigenic HPV-18 immortalized human keratinocytes transformed by nitrosomethylurea.

5 July 2018

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

5 July 2018

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A cell cycle regulator potentially involved in genesis of many tumor types

5 July 2018

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

5 July 2018

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The cell cycle and the retinoblastoma protein family

5 July 2018

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Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation

5 July 2018

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

5 July 2018

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Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas.

5 July 2018

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Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells

5 July 2018

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Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

5 July 2018

1 reference

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Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.

5 July 2018

1 reference

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Growth suppression by p16ink4 requires functional retinoblastoma protein

5 July 2018

1 reference

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5 July 2018

1 reference

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Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.

5 July 2018

1 reference

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Ribonucleic acid isolated by cesium chloride centrifugation

5 July 2018

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Distinctive traits of normal and tumor-derived human mammary epithelial cells expressed in a medium that supports long-term growth of both cell types

5 July 2018

1 reference

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5 July 2018

1 reference

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Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product

5 July 2018

1 reference

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HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes

5 July 2018

1 reference

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

5 July 2018

1 reference

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Genomic sequencing reveals a 5-methylcytosine-free domain in active promoters and the spreading of preimposed methylation patterns

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells

5 July 2018

1 reference

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

Whole genome amplification from a single cell: implications for genetic analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

Association of extended in vitro proliferative potential with loss of p16INK4 expression.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121409

29 October 2018

Tumor suppressor genes

1 reference

12 December 2020

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma

1 reference

12 December 2020

Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia.

1 reference

12 December 2020

Allelic loss of 9p21 and mutation of the CDKN2/p16 gene develop as early lesions during neoplastic progression in Barrett's esophagus

1 reference

12 December 2020

Interaction of HPV-18 and nitrosomethylurea in the induction of squamous cell carcinoma

1 reference

12 December 2020

Expression and amplification of cyclin genes in human breast cancer

1 reference

12 December 2020

P16 gene in uncultured tumours

1 reference

12 December 2020

Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas

1 reference

12 December 2020

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1 reference

12 December 2020

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

1 reference

12 December 2020

p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas

1 reference

12 December 2020

7

55

2892

Brenner A. J.

1995

1 reference

https://api.crossref.org/works/10.1128/MCB.18.4.1793

15 December 2024

39

7

980

Miller A. D.

1989

1 reference

https://api.crossref.org/works/10.1128/MCB.18.4.1793

Isolation and growth of human mammary epithelial cells

15 December 2024

51

1 reference

https://api.crossref.org/works/10.1128/MCB.18.4.1793

15 December 2024

Identifiers

1 reference

30 July 2017

1 reference

30 July 2017

1 reference