Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. (Q33993559)

30 July 2017

Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. (English)

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30 July 2017

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Robert C Murphy

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Edward A Dennis

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Christopher K Glass

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Christopher K Glass

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Christian R H Raetz

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Teresa A Garrett

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C Michael Reynolds

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Walter A Shaw

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Jeff D Moore

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Dale C Smith

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Anthony A Ribeiro

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Richard J Ulevitch

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Colleen Fearns

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Donna Reichart

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Chris Benner

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Shankar Subramaniam

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Richard Harkewicz

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Rebecca C Bowers-Gentry

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Matthew W Buczynski

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Jennifer A Cooper

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Raymond A Deems

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14 February 2006

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Journal of Lipid Research

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47

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1097-1111

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Analysis of nonvolatile lipids by mass spectrometry

30 July 2017

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Electrospray mass spectrometry of phospholipids

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A comprehensive classification system for lipids

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Toll-like receptors in the induction of the innate immune response

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Lipopolysaccharide endotoxins

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MD-2: the Toll 'gatekeeper' in endotoxin signalling

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Molecular basis of bacterial outer membrane permeability

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Therapeutics targeting the innate immune system

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Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.

21 January 2018

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Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia

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Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects.

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A network-based analysis of systemic inflammation in humans

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Inhibition of endotoxin response by synthetic TLR4 antagonists

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The detection and interpretation of endotoxaemia

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Mass spectrometry advances in lipidomica: collision-induced decomposition of Kdo2-lipid A.

21 January 2018

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Ca2+-induced phosphoethanolamine transfer to the outer 3-deoxy-D-manno-octulosonic acid moiety of Escherichia coli lipopolysaccharide. A novel membrane enzyme dependent upon phosphatidylethanolamine

21 January 2018

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Two-dimensional NMR spectroscopy and structures of six lipid A species from Rhizobium etli CE3. Detection of an acyloxyacyl residue in each component and origin of the aminogluconate moiety

21 January 2018

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High-resolution NMR spectroscopy of lipid A molecules containing 4-amino-4-deoxy-L-arabinose and phosphoethanolamine substituents. Different attachment sites on lipid A molecules from NH4VO3-treated Escherichia coli versus kdsA mutants of Salmonella

21 January 2018

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Toll-like receptor signalling

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Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

21 January 2018

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The Myc/Max/Mad network and the transcriptional control of cell behavior

21 January 2018

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

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A New Method for the Extraction of R Lipopolysaccharides

21 January 2018

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Heterogeneity of Antigenic-Side-Chain Length in Lipopolysaccharide from Escherichia coli 0111 and Salmonella typhimurium LT2

21 January 2018

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First Total Synthesis of the Re-Type Lipopolysaccharide This work was supported by the Research for the Future Program (No. 97L00502) from the Japan Society for the Promotion of Science. H.Y. is grateful for a JSPS Research Fellowship for Young Scie

21 January 2018

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Automated synthesis of oligosaccharides as a basis for drug discovery

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Lipid A modifications characteristic of Salmonella typhimurium are induced by NH4VO3 in Escherichia coli K12. Detection of 4-amino-4-deoxy-L-arabinose, phosphoethanolamine and palmitate

21 January 2018

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Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation

21 January 2018

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A PhoP/PhoQ-induced Lipase (PagL) that catalyzes 3-O-deacylation of lipid A precursors in membranes of Salmonella typhimurium

21 January 2018

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Expression cloning and biochemical characterization of a Rhizobium leguminosarum lipid A 1-phosphatase

21 January 2018

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Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A

21 January 2018

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MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli

21 January 2018

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A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant.

21 January 2018

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An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor

21 January 2018

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Taking toll: lipid A mimetics as adjuvants and immunomodulators

21 January 2018

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Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents

21 January 2018

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Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

21 January 2018

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4-Amino-4-deoxy-L-arabinose in LPS of enterobacterial R-mutants and its possible role for their polymyxin reactivity

21 January 2018

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The Envelope of Mycobacteria

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Rhizobium lipo-chitooligosaccharide nodulation factors: signaling molecules mediating recognition and morphogenesis

21 January 2018

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Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB.

21 January 2018

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A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A.

21 January 2018

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Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria

21 January 2018

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Crystal structure of CD14 and its implications for lipopolysaccharide signaling

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2 April 2022

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E5531, a pure endotoxin antagonist of high potency

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Molecular basis of bacterial outer membrane permeability revisited

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A simple method for the isolation and purification of total lipides from animal tissues

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First Total Synthesis of the Re-Type Lipopolysaccharide

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Bacterial endotoxin testing: a report on the methods, background, data, and regulatory history of extraction recovery efficiency

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Regulated covalent modifications of lipid A.

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Deletion of the heptosyltransferase genes rfaC and rfaF in Escherichia coli K-12 results in an Re-type lipopolysaccharide with a high degree of 2-aminoethanol phosphate substitution

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Identifiers

DOI

10.1194/JLR.M600027-JLR200

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30 July 2017

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