MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress (Q33987563)

30 July 2017

MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress (English)

1 reference

P38b MAP kinase Dmel_CG7393

30 July 2017

0 references

1 reference

MAP kinase activated protein-kinase-2 Dmel_CG3086

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Gerhard Seisenbacher

1

1 reference

PubMed ID

21829386

30 July 2017

Ernst Hafen

series ordinal

2

1 reference

PubMed ID

21829386

30 July 2017

Hugo Stocker

series ordinal

3

1 reference

30 July 2017

4 August 2011

1 reference

30 July 2017

1 reference

30 July 2017

7

1 reference

30 July 2017

8

1 reference

30 July 2017

e1002168

1 reference

Creative Commons Attribution 4.0 International

30 July 2017

start time

4 August 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi

5 July 2018

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The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

5 July 2018

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DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

5 July 2018

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Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation

5 July 2018

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Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation.

5 July 2018

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The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila

5 July 2018

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Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease.

5 July 2018

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A transient niche regulates the specification of Drosophila intestinal stem cells

5 July 2018

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A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

5 July 2018

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A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK

5 July 2018

1 reference

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The gut immune barrier and the blood-brain barrier: are they so different?

5 July 2018

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The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage

5 July 2018

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Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut

5 July 2018

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JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

5 July 2018

1 reference

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Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling

5 July 2018

1 reference

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MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

5 July 2018

1 reference

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Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis

5 July 2018

1 reference

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Crypt stem cells as the cells-of-origin of intestinal cancer

5 July 2018

1 reference

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IKK/NF-kappaB signaling in intestinal epithelial cells controls immune homeostasis in the gut.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Identification of stem cells in small intestine and colon by marker gene Lgr5

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases

5 July 2018

1 reference

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p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Melanotic mutants in Drosophila: pathways and phenotypes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

ASGE guideline: endoscopy in the diagnosis and treatment of inflammatory bowel disease

5 July 2018

1 reference

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Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

MAPKAP kinases - MKs - two's company, three's a crowd

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

A Drosophila p38 orthologue is required for environmental stress responses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Feedback control of the protein kinase TAK1 by SAPK2a/p38

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Mechanism of p38 MAP kinase activation in vivo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Distinct cellular functions of MK2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

A conserved docking motif in MAP kinases common to substrates, activators and regulators

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

In vivo regulation of tissue-specific and LPS-inducible expression of the Drosophila Cecropin genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150449

Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

Uncoupling the p38 MAPK kinase in IBD: a double edged sword?

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

Ultrastructure of the hindgut of Drosophila larvae, with special reference to the domains identified by specific gene expression patterns.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

A Delta-Notch signaling border regulated by Engrailed/Invected repression specifies boundary cells in the Drosophila hindgut

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

Regulation of the Drosophila p38b gene by transcription factor DREF in the adult midgut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

MAPK p38: alternative and nonstressful in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

Definition of Drosophila hemocyte subsets by cell-type specific antigens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

Epithelial NEMO links innate immunity to chronic intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002168

p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21829386

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

No Evidence for an Involvement of the P38 and JNK Mitogen-Activated Protein in Inflammatory Bowel Diseases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21829386

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Novel tissue units of regional differentiation in the gut epithelium of Drosopbila, as revealed by P-element-mediated detection of enhancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21829386

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1002168

1 reference

30 July 2017

1 reference

30 July 2017

1 reference

PubMed ID

21829386