Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways (Q33984585)

30 July 2017

Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways (English)

1 reference

polycystic kidney disease

30 July 2017

0 references

1 reference

Ayumi Takakura

1

1 reference

30 July 2017

Erik A Nelson

2

1 reference

30 July 2017

Nadeem Haque

3

1 reference

30 July 2017

Benjamin D Humphreys

4

1 reference

30 July 2017

Kambiz Zandi-Nejad

5

1 reference

30 July 2017

David A Frank

6

1 reference

30 July 2017

Jing Zhou

7

1 reference

30 July 2017

5 August 2011

1 reference

30 July 2017

Human Molecular Genetics

1 reference

30 July 2017

20

1 reference

30 July 2017

4143-4154

1 reference

30 July 2017

21

1 reference

Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Evaluation of the effect of pyrimethamine, an anti-malarial drug, on HIV-1 replication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: What is the appropriate serum level?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Renal injury is a third hit promoting rapid development of adult polycystic kidney disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Pkd1 inactivation induced in adulthood produces focal cystic disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Intrinsic epithelial cells repair the kidney after injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

The evolution of signalling pathways in animal development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

A road map for those who don't know JAK-STAT

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Signal transduction and transcriptional adaptation in embryonic heart development and during myocardial hypertrophy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Mechanisms of progression in autosomal dominant polycystic kidney disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Plasma pyrimethamine concentrations during long-term treatment for cerebral toxoplasmosis in patients with AIDS

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice.

5 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

Everolimus in patients with autosomal dominant polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

Sirolimus and kidney growth in autosomal dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188991

Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction

29 October 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR338

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects

21 January 2018

1 reference

12 December 2020

Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: a study of incidence and its association with pathological features and clinical outcome

1 reference

12 December 2020

Genetic Heterogeneity of Polycystic Kidney Disease in Europe1

1 reference

12 December 2020

Autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Inflammatory cytokine profile in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDR338

1 reference

release_v5hcqnsliffsteqmg7qy6y27yu

30 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/v5hcqnsliffsteqmg7qy6y27yu

24 November 2022

mapped directly with Wikidata item

PMCID

3188991

1 reference

30 July 2017

1 reference