Contributing factors to the pathobiology of asthma. The Th1/Th2 paradigm (Q33977245)

30 July 2017

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title

Contributing factors to the pathobiology of asthma. The Th1/Th2 paradigm (English)

1 reference

30 July 2017

0 references

Colavita AM

1

1 reference

PubMed ID

10907587

30 July 2017

Reinach AJ

series ordinal

2

1 reference

PubMed ID

10907587

30 July 2017

Peters SP

series ordinal

3

1 reference

30 July 2017

1 June 2000

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Clinics in Chest Medicine

30 July 2017

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30 July 2017

21

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30 July 2017

2

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30 July 2017

263-77, viii

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An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

The effects of nebulized recombinant interferon-gamma in asthmatic airways

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Increased expression of the CD80 accessory molecule by alveolar macrophages in asthmatic subjects and its functional involvement in allergen presentation to autologous TH2 lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5. Effect of glucocorticoid therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Therapeutic effects of antibodies to interleukin-5

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

The role of IL-13 and its receptor in allergy and inflammatory responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Effects of chronic anti-interleukin-5 monoclonal antibody treatment in a murine model of pulmonary inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Requirement for IL-13 independently of IL-4 in experimental asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Immune responses after immunization with plasmid DNA encoding Bet v 1, the major allergen of birch pollen

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Upregulation of B7.2, but not B7.1, on B cells from patients with allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Treatment of allergic airways disease with anti-IgE

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma?

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

B7 costimulation is required for IL-5 and IL-13 secretion by bronchial biopsy tissue of atopic asthmatic subjects in response to allergen stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Rush immunotherapy results in allergen-specific alterations in lymphocyte function and interferon-gamma production in CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Immunoregulatory networks in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Allergen-induced cytokine production in atopic disease and its relationship to disease severity

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Major histocompatibility complex (MHC) class II restriction, lymphokine production, and IgE regulation of house dust mite-specific T-cell clones

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

TRFK-5 reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Two types of mouse helper T-cell clone Implications for immune regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Treatment of cat allergy with T-cell reactive peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Long-term analysis of allergen-specific T cell clones from patients with asthma treated with allergen rush immunotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Aberrant interleukin (IL)-4 and IL-5 production in vitro by CD4+ helper T cells from atopic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Effects of interferon-alpha on cytokine profile, T cell receptor repertoire and peptide reactivity of human allergen-specific T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Stability of Th1 and Th2 populations

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Abnormal production of T helper 2 cytokines interleukin-4 and interleukin-5 by T cells from newborns with atopic parents

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Inhibition of allergen-induced IgE and IgG1 production by soluble IL-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Atopic allergy and other hypersensitivities editorial overview: technological advances and new insights into pathogenesis prelude novel therapeutic strategies

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Biology of human TH1 and TH2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

The Th1/Th2 paradigm and allergic disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Increased numbers of Th2-like CD4+ T cells in target organs and in the allergen-specific repertoire of allergic patients. Possible role of IL-4 produced by non-T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Identification of a common T/natural killer cell progenitor in human fetal thymus.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Measles and atopy in Guinea-Bissau

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

The inverse association between tuberculin responses and atopic disorder.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Anti-interleukin 5 strategies as a potential treatment for asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Inhibition of IgE formation and allergic inflammation by allergen gene immunization and by CpG motif immunostimulatory oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Early stages in the development of human T, natural killer and thymic dendritic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Helper T cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Essential role of Stat6 in IL-4 signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Interleukin-12 as a target for modulation of the inflammatory response in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Interleukin-13: central mediator of allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

Anti-interleukin-4 inhibits immunoglobulin E production in a murine model of atopic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0272-5231%2805%2970265-3

7 January 2021

10.1016/S0272-5231(05)70265-3

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10907587