Genetic regulation of the embryology of the pituitary gland and somatotrophs (Q33975032)

30 July 2017

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title

Genetic regulation of the embryology of the pituitary gland and somatotrophs (English)

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30 July 2017

Cohen LE

1

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30 July 2017

1 April 2000

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30 July 2017

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30 July 2017

12

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30 July 2017

2

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30 July 2017

99-106

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https://scigraph.springernature.com/pub.10.1385/endo:12:2:99

30 July 2017

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cites work

Combined pituitary deficiencies of growth hormone, thyroid stimulating hormone and prolactin due to Pit-1 gene mutation: a case report

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12 December 2020

Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency

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12 December 2020

A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency

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12 December 2020

Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility

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12 December 2020

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

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12 December 2020

Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype

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12 December 2020

A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally

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Targeted ablation of cells in the pituitary primordia of transgenic mice.

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Pituitary dwarfism in the R271W Pit-1 gene mutation

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Transgenic mice with inducible dwarfism.

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12 December 2020

Specification of pituitary cell lineages by the LIM homeobox gene Lhx3

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12 December 2020

Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain

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12 December 2020

Linkage mapping of the gene for the LIM-homeoprotein LIM3 (locus Lhx3) to mouse Chromosome 2

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12 December 2020

The homeodomain protein, Pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters

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12 December 2020

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions

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12 December 2020

Pituitary-directed leukemia inhibitory factor transgene causes Cushing's syndrome: neuro-immune-endocrine modulation of pituitary development

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12 December 2020

Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain

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12 December 2020

Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia

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12 December 2020

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis

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12 December 2020

The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation.

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12 December 2020

A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency.

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12 December 2020

Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene

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12 December 2020

The PROP1 2-base pair deletion is a common cause of combined pituitary hormone deficiency

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12 December 2020

Pro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency.

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12 December 2020

A new step understood in the cascade of tissue-specific regulators orchestrating pituitary lineage determination: the Prophet of Pit-1 (Prop-1).

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12 December 2020

A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency

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12 December 2020

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

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12 December 2020

The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3.

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12 December 2020

The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency

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12 December 2020

Multistep signaling requirements for pituitary organogenesis in vivo

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12 December 2020

Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo.

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12 December 2020

Dissection of functional domains of the pituitary-specific transcription factor GHF-1.

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12 December 2020

Mutations in PROP1 cause familial combined pituitary hormone deficiency

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12 December 2020

P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development

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12 December 2020

A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene.

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12 December 2020

Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome

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12 December 2020

Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor

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Molecular basis of the little mouse phenotype and implications for cell type-specific growth

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Pitx2 determines left-right asymmetry of internal organs in vertebrates.

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12 December 2020

Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors

1 reference

12 December 2020

Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C)

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12 December 2020

Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency

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12 December 2020

The PTX family of homeodomain transcription factors during pituitary developments.

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12 December 2020

Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse

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12 December 2020

Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant

1 reference

12 December 2020

A mutational hot spot in the Prop-1 gene in Russian children with combined pituitary hormone deficiency

1 reference

12 December 2020

Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency

1 reference

12 December 2020

Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope.

1 reference

12 December 2020

TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins

1 reference

12 December 2020

A "hot spot" in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates.

1 reference

12 December 2020

The Ames dwarf gene is required for Pit-1 gene activation.

1 reference

12 December 2020

Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity

1 reference

12 December 2020

Central hypothyroidism reveals compound heterozygous mutations in the Pit-1 gene

1 reference

12 December 2020

GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice

1 reference

12 December 2020

Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues

1 reference

12 December 2020

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

1 reference

12 December 2020

Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development

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12 December 2020

The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis

1 reference

12 December 2020

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene

1 reference

12 December 2020

GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function

1 reference

12 December 2020

Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation.

1 reference

12 December 2020

Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression

1 reference

12 December 2020

P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1.

1 reference

12 December 2020

Clinical and molecular characterization of a Brazilian patient with Pit-1 deficiency

1 reference

12 December 2020

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

1 reference

12 December 2020

Identifiers

DOI

10.1385/ENDO:12:2:99

1 reference

PubMed ID

10905370

Dimensions Publication ID

30 July 2017

0 references

1 reference

PubMed ID

10905370