Mechanisms of aging: an appraisal of the oxidative stress hypothesis (Q33961197)

30 July 2017

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title

Mechanisms of aging: an appraisal of the oxidative stress hypothesis (English)

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30 July 2017

1

Rajindar S Sohal

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30 July 2017

Robin J Mockett

2

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PubMed ID

12208343

30 July 2017

William C Orr

series ordinal

3

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30 July 2017

1 September 2002

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Free Radical Biology and Medicine

30 July 2017

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30 July 2017

33

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30 July 2017

5

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30 July 2017

575-586

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Aging: a theory based on free radical and radiation chemistry

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Oxidative stress, caloric restriction, and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Downregulation of cellular metabolism during environmental stress: mechanisms and implications

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Hibernation and longevity in the Turkish hamster Mesocricetus brandti

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Life-lengthening effects of gamma-radiation on the adult housefly, Musca domestica.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effects of ethidium bromide on development and aging of Drosophila: implications for the free radical theory of aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effects of diethyldithiocarbamate on life span, metabolic rate, superoxide dismutase, catalase, inorganic peroxides and glutathione in the adult male housefly, Musca domestica

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

The genetics of aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Metabolism and aging in the nematode Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

A conserved regulatory system for aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Sexual activity reduces lifespan of male fruitflies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Extended life-span conferred by cotransporter gene mutations in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Extended life-span and stress resistance in the Drosophila mutant methuselah

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Antioxidant defenses and metabolic depression. The hypothesis of preparation for oxidative stress in land snails

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Protein oxidation in aging, disease, and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

1 reference

7 January 2021

Lipofuscin: mechanisms of age-related accumulation and influence on cell function

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Mitochondrial free radical production and aging in mammals and birds

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Biochemical correlates of longevity in two closely related rodent species

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Protein oxidative damage is associated with life expectancy of houseflies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

DNA oxidative damage and life expectancy in houseflies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Levels of lipid peroxidation in hepatocytes isolated from aging rats fed an antioxidant-free diet

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

The free radical hypothesis of aging: an appraisal of the current status

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Vitamin and mineral supplement use and mortality in a US cohort

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

The antioxidant supplement myth

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effect of Antioxidants on Life-Span of C57BL Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effect of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone on protein oxidation and life span.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

The spin-trap N-tert-alpha-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance of oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Expression of human FALS SOD in motorneurons of Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

CuZn-SOD promoter-driven expression in the Drosophila central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Superoxide radical: controversies, contradictions, and paradoxes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Oxygen-reactive species and antioxidant responses during development: the metabolic paradox of cellular differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

A correlation between DNA repair capacity and longevity in adult Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Effect of age on endogenous DNA single-strand breakage, strand break induction and repair in the adult housefly, Musca domestica

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Relationship between life expectancy and endogenous DNA single-strand breakage, strand break induction and DNA repair capacity in the adult housefly, Musca domestica

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Protein oxidation and proteolysis during aging and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

High-quality life extension by the enzyme peptide methionine sulfoxide reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2802%2900886-9

7 January 2021

10.1016/S0891-5849(02)00886-9

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

12208343