The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control (Q33956671)

30 July 2017

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title

The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control (English)

1 reference

30 July 2017

Decker MW

1

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30 July 2017

Meyer MD

series ordinal

2

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30 July 2017

Sullivan JP

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

1 October 2001

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Expert Opinion on Investigational Drugs

30 July 2017

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30 July 2017

10

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30 July 2017

10

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30 July 2017

1819-1830

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The promise and pitfalls of a nicotinic cholinergic approach to pain management

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Human neuronal nicotinic receptors

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The TiPS lecture. The nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels

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The alpha-bungarotoxin-binding nicotinic acetylcholine receptor from rat brain contains only the alpha7 subunit.

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Analgesic profile of the nicotinic acetylcholine receptor agonists, (+)-epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain

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Nicotinic cholinergic receptors: potential targets for inflammatory pain relief

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Antihyperalgesic activity of epibatidine in the formalin model of facial pain

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A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand

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Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice.

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Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors

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The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain.

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ABT-594, a novel cholinergic channel modulator, is efficacious in nerve ligation and diabetic neuropathy models of neuropathic pain.

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Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice

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Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats

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Synthesis, optical resolution, absolute configuration, and preliminary pharmacology of (+)- and (-)-cis-2,3,3a,4,5,9b-hexahydro-1-methyl-1H- pyrrolo-[3,2-h]isoquinoline, a structural analog of nicotine

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Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo

21 January 2018

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3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner

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Diversity of neuronal nicotinic acetylcholine receptors: lessons from behavior and implications for CNS therapeutics

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Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils.

21 January 2018

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Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay

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The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model

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Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

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The antinociception produced by microinjection of a cholinergic agonist in the ventromedial medulla is mediated by noradrenergic neurons in the A7 catecholamine cell group.

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The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594.

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Epibatidine binding sites and activity in the spinal cord

21 January 2018

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Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists

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Sex differences in cholinergic analgesia I: a supplemental nicotinic mechanism in normal females

21 January 2018

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Presynaptic nicotinic ACh receptors

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The involvement of spinal Ca(2+)/calmodulin-protein kinase II in nicotine-induced antinociception in mice

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Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice

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Sex differences in cocaine- and nicotine-induced antinociception in the rat.

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10.1517/13543784.10.10.1819

21 January 2018

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30 July 2017

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