Central nervous system drug development: an integrative biomarker approach toward individualized medicine (Q33947007)

30 July 2017

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title

Central nervous system drug development: an integrative biomarker approach toward individualized medicine (English)

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30 July 2017

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B Gomez-Mancilla

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30 July 2017

E Marrer

2

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30 July 2017

J Kehren

3

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30 July 2017

A Kinnunen

4

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30 July 2017

G Imbert

5

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30 July 2017

R Hillebrand

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30 July 2017

M Bergström

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30 July 2017

M E Schmidt

8

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30 July 2017

1 October 2005

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30 July 2017

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30 July 2017

2

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30 July 2017

683-695

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30 July 2017

4

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Dose-dependent neuronal injury after traumatic brain injury

30 July 2017

1 reference

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Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Biomarkers and surrogate markers: an FDA perspective

5 July 2018

1 reference

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Human monoclonal antibodies against amyloid-beta from healthy adults

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Methods of comparative proteomic profiling for disease diagnostics

5 July 2018

1 reference

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Proteomics analysis of human cerebrospinal fluid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection

5 July 2018

1 reference

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Biomarker discovery and validation: technologies and integrative approaches

5 July 2018

1 reference

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Therapeutic monitoring of antidepressants in the era of pharmacogenetics studies.

5 July 2018

1 reference

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Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant

5 July 2018

1 reference

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Progress in the use of microarray technology to study the neurobiology of disease

5 July 2018

1 reference

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Metabolomics by numbers: acquiring and understanding global metabolite data

5 July 2018

1 reference

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Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization.

5 July 2018

1 reference

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Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain

5 July 2018

1 reference

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Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes

5 July 2018

1 reference

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The ultimate chip shot: can microarray technology deliver for neuroscience?

5 July 2018

1 reference

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

5 July 2018

1 reference

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Pharmacokinetics of radiolabelled anticancer drugs for positron emission tomography

5 July 2018

1 reference

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Evanescent resonator chips: a universal platform with superior sensitivity for fluorescence-based microarrays

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

DNA arrays and neurobiology--what's new and what's next?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Imaging amyloid-beta deposits in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

High-quality RNA from cells isolated by laser capture microdissection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Beta-amyloid (Abeta) protein in cerebrospinal fluid as a biomarker for Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Nuclei and subnuclei gene expression profiling in mammalian brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Patterns of cerebrospinal fluid pathology correlate with disease progression in multiple sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Microarrays in brain research: the good, the bad and the ugly.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Protein microarrays for gene expression and antibody screening

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Gene chips and arrays revealed: a primer on their power and their uses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Gene expression profiles of laser-captured adjacent neuronal subtypes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Antibodies from phage display libraries as immunochemical reagents.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Expression monitoring by hybridization to high-density oligonucleotide arrays

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Time course of 5-HT2A receptor occupancy in the human brain after a single oral dose of the putative antipsychotic drug MDL 100,907 measured by positron emission tomography

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Use of a cDNA microarray to analyse gene expression patterns in human cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Positron emission tomography of in-vivo binding characteristics of atypical antipsychotic drugs. Review of D2 and 5-HT2 receptor occupancy studies and clinical response.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Quantitative monitoring of gene expression patterns with a complementary DNA microarray

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Enzyme immunoassay techniques an overview

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions

5 July 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Expression profiling identifies responder and non-responder phenotypes to interferon-beta in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Valproic acid blood genomic expression patterns in children with epilepsy - a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Altered response to mirtazapine on gene expression profile of lymphocytes from Alzheimer's patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

The effect of citalopram on gene expression profile of Alzheimer lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Expression of CCR7 in multiple sclerosis: implications for CNS immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Weight gain with antipsychotic drugs: the role of the 5-HT2C receptor (HTR2C) and other genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Cerebrospinal fluid biomarkers for disease stage and intensity in cognitively impaired patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Synthesis of 11C-amides using [11C]carbon monoxide and in situ activated amines by palladium-mediated carboxaminations

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Pindolol augmentation of selective serotonin reuptake inhibitors: PET evidence that the dose used in clinical trials is too low.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers

21 January 2018

1 reference

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Discovering genes: the use of microarrays and laser capture microdissection in pain research

21 January 2018

1 reference

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Plasma levels of alpha beta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

The molecular medicine revolution and psychiatry: bridging the gap between basic neuroscience research and clinical psychiatry.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201325

Evaluation of the safety and immunogenicity of synthetic A 42 (AN1792) in patients with AD

29 October 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.4.683

Linear mRNA amplification from as little as 5 ng total RNA for global gene expression analysis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16489375

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1602/NEURORX.2.4.683

1 reference

30 July 2017

1 reference

30 July 2017

1 reference