Relative roles of somatic and Darwinian evolution in shaping the antibody response (Q33941984)

30 July 2017

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title

Relative roles of somatic and Darwinian evolution in shaping the antibody response (English)

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30 July 2017

Diaz M

1

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PubMed ID

10852106

30 July 2017

Klinman NR

series ordinal

2

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30 July 2017

1 January 2000

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30 July 2017

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30 July 2017

21

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30 July 2017

2-3

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30 July 2017

89-102

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https://scigraph.springernature.com/pub.10.1385/ir:21:2-3:89

30 July 2017

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cites work

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Functions of the MDM2 oncoprotein

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Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

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Positive and negative selection events during B lymphopoiesis

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Evolution of somatic hypermutation and gene conversion in adaptive immunity

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p53 mediates apoptosis induced by c-Myc activation in hypoxic or gamma irradiated fibroblasts

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Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice

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Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells

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Tolerance susceptibility of newly generating memory B cells.

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Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro

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B lymphocytes may escape tolerance by revising their antigen receptors

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Surrogate light chain-dependent selection of Ig heavy chain V regions.

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The surrogate light chain in B-cell development.

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Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene

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Receptor editing and commitment in B lymphocytes.

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12 December 2020

Comparative expression of adult and fetal V gene repertoires

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Mismatch repair and immunoglobulin gene hypermutation: did we learn something?

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The cellular origins of memory B cells

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The mannose receptor is a pattern recognition receptor involved in host defense

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The somatic generation of immune recognition

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Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2

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12 December 2020

Origin of murine B cell lineages

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Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

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Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation

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12 December 2020

The mutagenesis proteins UmuD' and UmuC prevent lethal frameshifts while increasing base substitution mutations

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B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation.

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12 December 2020

Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains

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12 December 2020

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences

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12 December 2020

The generation of B-cell memory: a working hypothesis

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12 December 2020

Somatic generation of antibody diversity

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12 December 2020

Receptor editing occurs frequently during normal B cell development.

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12 December 2020

Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition.

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12 December 2020

Germinal center founder cells display propensity for apoptosis before onset of somatic mutation

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12 December 2020

A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly.

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12 December 2020

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.

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Molecular mechanisms governing reading frame choice of immunoglobulin diversity genes

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The role of components of recombination signal sequences in immunoglobulin gene segment usage: a V81x model.

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Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice

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12 December 2020

A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks

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Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

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Reading of D genes in variable frames as a source of antibody diversity

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Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu

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Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation

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Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.

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Predominance of nonproductive rearrangements of VH81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains.

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Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation.

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The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice

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In vitro tolerance induction of bone marrow cells: a marker for B cell maturation

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12 December 2020

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

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12 December 2020

Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers

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12 December 2020

C3d of complement as a molecular adjuvant: bridging innate and acquired immunity

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12 December 2020

Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies.

1 reference

12 December 2020

The expression of the Ig H chain repertoire in developing bone marrow B lineage cells

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12 December 2020

Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice

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12 December 2020

Rearrangements of DNA mediated by terminal transferase

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12 December 2020

The dynamic structure of the germinal center.

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12 December 2020

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance

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12 December 2020

The joining of V and J gene segments creates antibody diversity

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12 December 2020

A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

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12 December 2020

Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity

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12 December 2020

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers

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12 December 2020

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

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12 December 2020

Identifiers

DOI

10.1385/IR:21:2-3:89

1 reference

PubMed ID

10852106

Dimensions Publication ID

30 July 2017

0 references

1 reference

PubMed ID

10852106