Neuronal cell death in Huntington's disease: a potential role for dopamine (Q33934225)

30 July 2017

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title

Neuronal cell death in Huntington's disease: a potential role for dopamine (English)

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30 July 2017

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R J Jakel

1

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PubMed ID

10838590

30 July 2017

W F Maragos

series ordinal

2

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30 July 2017

1 June 2000

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30 July 2017

Trends in Neurosciences

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30 July 2017

23

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30 July 2017

6

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30 July 2017

239-245

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Neuropathological classification of Huntington's disease

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Selective sparing of a class of striatal neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Differential loss of striatal projection neurons in Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Biochemical abnormalities in Huntington's chorea brains

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Regional mitochondrial respiratory activity in Huntington's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Cyanide-induced parkinsonism: a clinicopathologic report.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

A pure parkinsonian syndrome following acute carbon monoxide intoxication

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: a type of hypoxic (energy deficient) brain damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Defect in succinate oxidation by isolated muscle mitochondria in a patient with symmetrical lesions in the basal ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Minireview. Emerging new functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Alternative excitotoxic hypotheses

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

NMDA receptor losses in putamen from patients with Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Reactive oxygen species and the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Increased vulnerability to 3-nitropropionic acid in an animal model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Ubisemiquinones as obligatory intermediates in the electron transfer from NADH to ubiquinone

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Histochemical investigations on succinic dehydrogenase in the central nervous system. V. The diencephalon and basal telencephalic centres of the guinea pig.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Histochemical localization of cytochrome oxidase in the hippocampus: Correlation with specific neuronal types and afferent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Anatomic correlation of NMDA and 3H-TCP-labeled receptors in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Distribution of catechol compounds in human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopaminergic modulation of excitotoxicity in rat striatum: Evidence from nigrostriatal lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Differential neurotoxicity induced by L-DOPA and dopamine in cultured striatal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Toxicity of Dopamine to Striatal Neurons In Vitro and Potentiation of Cell Death by a Mitochondrial Inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Catecholamine toxicity in cerebral cortex in dissociated cell culture

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Mechanisms of dopamine-induced cell death in cultured rat forebrain neurons: interactions with and differences from glutamate-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopamine turnover and glutathione oxidation: implications for Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

L-dopa increases nigral production of hydroxyl radicals in vivo: potential L-dopa toxicity?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

The functional significance of the pentose phosphate pathway in synaptosomes: protection against peroxidative damage by catecholamines and oxidants.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Neurotoxicity of endogenous cysteinylcatechols.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Monoamine neurotransmitters in diffuse reversible forebrain ischemia and early recirculation: increased dopaminergic activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Substantia nigra lesion protects against ischemic damage in the striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Excitotoxicity of NMDA and kainic acid is modulated by nigrostriatal dopaminergic fibres

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Modulatory Effect of Dopamine on High-Affinity Glutamate Uptake in the Rat Striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Inhibition of glutamate transport in synaptosomes by dopamine oxidation and reactive oxygen species.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

L-glutamate-evoked release of dopamine from synaptosomes of the rat striatum: involvement of AMPA and N-methyl-D-aspartate receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

The role of N-methyl-D-aspartate receptors in the regulation of physiologically released dopamine.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Nitric oxide inhibits [3H]dopamine uptake.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Reciprocal dopamine-glutamate modulation of release in the basal ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

2,4,5-Trihydroxyphenylalanine (6-hydroxy-DOPA) displaces [3H]AMPA binding in rat striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopaminergic modulation of early signs of excitotoxicity in visualized rat neostriatal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopamine-induced protection of striatal neurons against kainate receptor-mediated glutamate cytotoxicity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopaminergic modulation of excitatory postsynaptic currents in rat neostriatal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

The effect of dopamine depletion on the H2O2 production in the rat striatum following transient middle cerebral artery occlusion.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Levodopa induces apoptosis in cultured neuronal cells--a possible accelerator of nigrostriatal degeneration in Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Nigrostriatal Dopaminergic Neurons Remain Undamaged in Rats Given High Doses of l-DOPA and Carbidopa Chronically

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Mitochondrial respiratory chain function in multiple system atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Metabolic inhibition enhances selective toxicity of L-DOPA toward mesencephalic dopamine neurons in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Deprenyl suppresses the oxidant stress associated with increased dopamine turnover

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

The high sensitivity to rotenone of striatal dopamine uptake suggests the existence of a constitutive metabolic deficiency in dopaminergic neurons from the substantia nigra.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Parkinson disease: a new link between monoamine oxidase and mitochondrial electron flow

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Predictive test for Huntington's chorea

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Elevated serotonin and reduced dopamine in subregionally divided Huntington's disease striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Huntington's chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Increased Cerebrospinal Fluid Dopamine and 3,4‐Dihydroxyphenylacetic Acid Levels in Huntington's Disease: Evidence for an Overactive Dopaminergic Brain Transmission

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Amino acid neurotransmitter abnormalities in Huntington's disease and the quinolinic acid animal model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Decreased glutamic acid and increased 5-hydroxytryptamine in Huntington's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

In vivo autoxidation of dopamine in guinea pig striatum increases with age.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Organization of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntington's disease and schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Nigral dopamine type-1 receptors are reduced in Huntington's disease: a postmortem autoradiographic study using [3H]SCH 23390 and correlation with [3H]forskolin binding

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Heterogeneous dopamine receptor changes in early and late Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopamine D1 receptor number--a sensitive PET marker for early brain degeneration in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Striatal D1 and D2 receptor binding in patients with Huntington's disease and other choreas. A PET study

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Striatal glucose metabolism and dopamine D2 receptor binding in asymptomatic gene carriers and patients with Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: contribution of calcium conductances

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Coupling of D1 dopamine receptors to the guanine nucleotide binding protein Gs is deficient in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Catecholamines potentiate amyloid beta-peptide neurotoxicity: involvement of oxidative stress, mitochondrial dysfunction, and perturbed calcium homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901568-X

7 January 2021

10.1016/S0166-2236(00)01568-X

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10838590