P-glycoprotein, secretory transport, and other barriers to the oral delivery of anti-HIV drugs (Q33933495)

30 July 2017

title

P-glycoprotein, secretory transport, and other barriers to the oral delivery of anti-HIV drugs (English)

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30 July 2017

Aungst BJ

1

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30 July 2017

language of work or name

English

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publication date

1 October 1999

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Advanced Drug Delivery Reviews

30 July 2017

published in

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30 July 2017

volume

39

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30 July 2017

issue

1-3

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30 July 2017

page(s)

105-116

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Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex.

30 July 2017

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Determination of the pKa and pH-solubility behavior of an ionizable cyclic carbamate, (S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4- (trifluoromethyl)-2H-3,1-benzoxazin-2-one (DMP 266)

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The influence of peptide structure on transport across Caco-2 cells

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Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A

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Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers

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ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans

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7 January 2021

Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers

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7 January 2021

Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism

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7 January 2021

The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa

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A general pattern for substrate recognition by P-glycoprotein.

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7 January 2021

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers

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Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport

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Involvement of intestinal P-glycoprotein in the restricted absorption of methylprednisolone from rat small intestine

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7 January 2021

Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine

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7 January 2021

Inhibition of intestinal P-glycoprotein and effects on etoposide absorption.

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7 January 2021

Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine

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7 January 2021

Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells

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7 January 2021

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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7 January 2021

Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP

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7 January 2021

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

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7 January 2021

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells

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7 January 2021

Polarized efflux of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers

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7 January 2021

Calcein is excreted from the intestinal mucosal cell membrane by the active transport system

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7 January 2021

Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells)

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7 January 2021

Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells

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7 January 2021

Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein

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7 January 2021

Human canalicular multispecific organic anion transporter (cMOAT) is expressed in human lung, gastric, and colorectal cancer cells

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7 January 2021

Characterization of guanidine transport in human renal brush border membranes

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7 January 2021

Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein

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7 January 2021

Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells

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7 January 2021

P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

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7 January 2021

Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells

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7 January 2021

Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat.

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7 January 2021

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

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7 January 2021

Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier

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7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900022-8

7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

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https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900022-8

7 January 2021

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900022-8

7 January 2021

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

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7 January 2021

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease

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https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900022-8

7 January 2021

Cross-resistance to anti-HIV nucleoside analogs in multidrug-resistant human cells

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https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900022-8

7 January 2021

Resistance of HIV-1 to AZT might also involve the cellular expression of multidrug resistance P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900022-8

7 January 2021

Saquinavir pharmacokinetics alone and in combination with nelfinavir in HIV-infected patients

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900022-8

7 January 2021

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

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7 January 2021

Comparison of solutol HS 15, Cremophor EL and novel ethoxylated fatty acid surfactants as multidrug resistance modification agents

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https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900022-8

7 January 2021

The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900022-8

7 January 2021

10.1016/S0169-409X(99)00022-8

Identifiers

DOI

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30 July 2017

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