A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: characterization of the paratope (Q33931214)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24878961%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: characterization of the paratope (English)

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19 March 2020

6

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19 March 2020

author name string

Xiaolei Zhuang

1

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19 March 2020

Stephen J Stahl

2

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19 March 2020

Norman R Watts

3

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19 March 2020

Michael A DiMattia

4

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19 March 2020

Alasdair C Steven

5

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19 March 2020

language of work or name

English

0 references

publication date

30 May 2014

1 reference

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Journal of Biological Chemistry

19 March 2020

published in

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19 March 2020

volume

289

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19 March 2020

issue

29

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19 March 2020

page(s)

20222-20233

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The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway.

19 March 2020

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5 July 2018

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Characterization of novel inhibitors of HIV-1 replication that function via alteration of viral RNA processing and rev function

5 July 2018

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Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization

5 July 2018

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Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev

5 July 2018

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5 July 2018

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5 July 2018

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Creation of a novel peptide with enhanced nuclear localization in prostate and pancreatic cancer cell lines

5 July 2018

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Structural basis for cooperative RNA binding and export complex assembly by HIV Rev

5 July 2018

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5 July 2018

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Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element

5 July 2018

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Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

5 July 2018

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Nuclear localization of cell-penetrating peptides is dependent on endocytosis rather than cytosolic delivery in CHO cells

5 July 2018

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HIV-1 Rev protein assembles on viral RNA one molecule at a time

5 July 2018

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An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection

5 July 2018

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Analysis of a 17-amino acid residue, virus-neutralizing microantibody.

5 July 2018

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5 July 2018

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Application of the Spot method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding

5 July 2018

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Efficient CD4 binding and immunosuppressive properties of the 13B8.2 monoclonal antibody are displayed by its CDR-H1-derived peptide CB1.

5 July 2018

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Structural model for the cooperative assembly of HIV-1 Rev multimers on the RRE as deduced from analysis of assembly-defective mutants

5 July 2018

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5 July 2018

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5 July 2018

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Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells

5 July 2018

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5 July 2018

THE HIV-1 REV PROTEIN

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The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals

5 July 2018

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HIV-1: fifteen proteins and an RNA

5 July 2018

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Three-dimensional structure of HIV-1 Rev protein filaments

5 July 2018

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5 July 2018

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A complementarity-determining region synthetic peptide acts as a miniantibody and neutralizes human immunodeficiency virus type 1 in vitro

5 July 2018

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HIV-1 Rev expressed in recombinant Escherichia coli: purification, polymerization, and conformational properties

5 July 2018

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Computational alanine scanning of protein-protein interfaces

5 July 2018

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KFC2: a knowledge-based hot spot prediction method based on interface solvation, atomic density, and plasticity features.

21 January 2018

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Effects of the TAT peptide orientation and relative location on the protein transduction efficiency

21 January 2018

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Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

21 January 2018

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A peptide mimetic of an anti-CD4 monoclonal antibody by rational design

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24878961

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.581090

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24878961%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24878961%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference