Exendin-4 improves blood glucose control in both young and aging normal non-diabetic mice, possible contribution of beta cell independent effects (Q33927198)

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English	Exendin-4 improves blood glucose control in both young and aging normal non-diabetic mice, possible contribution of beta cell independent effects	scientific article

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scholarly article

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Europe PubMed Central

30 July 2017

Exendin-4 improves blood glucose control in both young and aging normal non-diabetic mice, possible contribution of beta cell independent effects (English)

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Europe PubMed Central

30 July 2017

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Zhanfang Kang

2

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Rongrong Fan

1

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Juliana Chung-ngor Chan

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Juliana Chan

4

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Lan He

3

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Europe PubMed Central

30 July 2017

Gang Xu

5

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Europe PubMed Central

30 July 2017

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publication date

31 May 2011

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Europe PubMed Central

30 July 2017

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Europe PubMed Central

30 July 2017

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Europe PubMed Central

30 July 2017

5

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Europe PubMed Central

30 July 2017

e20443

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Europe PubMed Central

30 July 2017

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Creative Commons Attribution 4.0 International

31 May 2011

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3105063/fullTextXML

based on heuristic

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Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105063

5 July 2018

Adaptive beta-cell proliferation is severely restricted with advanced age.

1 reference

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5 July 2018

Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice

1 reference

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5 July 2018

Exenatide sensitizes insulin-mediated whole-body glucose disposal and promotes uptake of exogenous glucose by the liver

1 reference

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5 July 2018

Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis

1 reference

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5 July 2018

Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model

1 reference

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5 July 2018

Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway

1 reference

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5 July 2018

GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors

1 reference

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5 July 2018

Biology of incretins: GLP-1 and GIP

1 reference

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5 July 2018

Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets

1 reference

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5 July 2018

Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis

1 reference

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Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice

1 reference

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5 July 2018

Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats

1 reference

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Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.

1 reference

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Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase

1 reference

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cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

1 reference

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Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105063

5 July 2018

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105063

5 July 2018

Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling

1 reference

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Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans.

2 references

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5 July 2018

https://pubmed.ncbi.nlm.nih.gov/21655268

12 December 2020

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inferred from PubMed ID database lookup

Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes

1 reference

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5 July 2018

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105063

5 July 2018

Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats.

1 reference

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5 July 2018

A role for glucagon-like peptide-1 in the central regulation of feeding

1 reference

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Relationship of glucagon suppression by insulin and somatostatin to the ambient glucose concentration

1 reference

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Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas

1 reference

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5 July 2018

Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat.

1 reference

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21 January 2018

Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas

1 reference

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Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis

1 reference

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21 January 2018

Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020443

21 January 2018

Glucagon receptor signaling is essential for control of murine hepatocyte survival

1 reference

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21 January 2018

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020443

21 January 2018

Exendin-4 dose-dependently stimulates somatostatin and insulin secretion in perfused rat pancreas

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020443

21 January 2018

Interrelationship among insulin, glucagon and somatostatin secretory responses to exendin-4 in the perfused rat pancreas

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020443

21 January 2018

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020443

21 January 2018

The effects of GLP-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020443

21 January 2018

Effects of 3 Months of Continuous Subcutaneous Administration of Glucagon-Like Peptide 1 in Elderly Patients With Type 2 Diabetes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020443

21 January 2018

Partial pancreatectomy in adult humans does not provoke beta-cell regeneration

1 reference

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21 January 2018

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020443

21 January 2018

Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats

1 reference

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GLP-1/exendin-4 facilitates β-cell neogenesis in rat and human pancreatic ducts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655268

12 December 2020

based on heuristic

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Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of Glucose Stimulation of Somatostatin and Insulin Release from Glucose Inhibition of Glucagon Release in the Isolated Perfused Rat Pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat gastric somatostatin and gastrin release: interactions of exendin-4 and truncated glucagon-like peptide-1 (GLP-1) amide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655268

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based on heuristic

inferred from PubMed ID database lookup

Effect of aging on B-cell function and replication in rat pancreas after 90% pancreatectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0020443

1 reference

Europe PubMed Central

30 July 2017

2011PLoSO...620443F

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1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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