Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial. (Q33925164)

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English	Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial.	scientific article

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4 April 2020

Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial (English)

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4 April 2020

phase II clinical trial

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metastatic breast cancer

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Serafin Morales

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Mark R. Lackner

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Denise A Yardley

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Denise A Yardley

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Edith A Perez

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Ian E Krop

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Eric Winer

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Mika Derynck

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Susanne Vallentin

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Susanne Vallentin

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Steven Gendreau

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Steven Gendreau

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Gallia Levy

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author name string

Ingrid A Mayer

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Vinod Ganju

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Maura Dickler

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Stephen Johnston

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Bohuslav Melichar

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Andres Forero-Torres

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Soo Chin Lee

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Richard de Boer

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Katarina Petrakova

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Martine Piccart

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Matthew Ellis

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Jiaheng Qiu

22

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Jing He

23

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Peter Schmid

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publication date

4 May 2016

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Lancet Oncology Commission

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17

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811-821

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6

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4 April 2020

First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors

1 reference

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5 July 2018

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

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5 July 2018

Characterization of breast cancers with PI3K mutations in an academic practice setting using SNaPshot profiling

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5 July 2018

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

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5 July 2018

PIK3CA genotype and a PIK3CA mutation-related gene signature and response to everolimus and letrozole in estrogen receptor positive breast cancer

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5 July 2018

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

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5 July 2018

Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer

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5 July 2018

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer

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5 July 2018

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

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Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models

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5 July 2018

New strategies in estrogen receptor-positive breast cancer

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PIK3CA mutation associates with improved outcome in breast cancer.

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Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer

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Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

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Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2†.

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29 October 2018

Mutational analysis of PI3K/AKT signaling pathway in tamoxifen exemestane adjuvant multinational pathology study.

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29 October 2018

Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study

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Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer

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29 October 2018

Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials

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Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women

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7 January 2021

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10.1016/S1470-2045(16)00106-6

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4 April 2020

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