Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial (Q33919074)

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English	Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial	scientific article

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial (English)

1 reference

Europe PubMed Central

30 July 2017

0 references

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based on heuristic

inferred from title

dexmedetomidine

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based on heuristic

inferred from title

Eugene Wesley Ely

9

object named as

E Wesley Ely

1 reference

Europe PubMed Central

30 July 2017

Ayumi K Shintani

6

object named as

Ayumi K Shintani

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Europe PubMed Central

30 July 2017

author name string

Pratik P Pandharipande

1

1 reference

Europe PubMed Central

30 July 2017

Robert D Sanders

2

1 reference

Europe PubMed Central

30 July 2017

Timothy D Girard

3

1 reference

Europe PubMed Central

30 July 2017

Stuart McGrane

4

1 reference

Europe PubMed Central

30 July 2017

Jennifer L Thompson

5

1 reference

Europe PubMed Central

30 July 2017

Daniel L Herr

7

1 reference

Europe PubMed Central

30 July 2017

Mervyn Maze

8

1 reference

Europe PubMed Central

30 July 2017

MENDS investigators

10

1 reference

Europe PubMed Central

30 July 2017

publication date

16 March 2010

1 reference

Europe PubMed Central

30 July 2017

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Europe PubMed Central

30 July 2017

14

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Europe PubMed Central

30 July 2017

2

1 reference

Europe PubMed Central

30 July 2017

R38

1 reference

Europe PubMed Central

30 July 2017

https://scigraph.springernature.com/pub.10.1186/cc8916

0 references

Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis

1 reference

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5 July 2018

Days of delirium are associated with 1-year mortality in an older intensive care unit population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Sedation improves early outcome in severely septic Sprague Dawley rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Sleep in the ICU: potential mechanisms and clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Sedation & immunomodulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Central sympatholytics prolong survival in experimental sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Opioids and infections in the intensive care unit should clinicians and patients be concerned?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Subsyndromal delirium in the ICU: evidence for a disease spectrum

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5 July 2018

Alpha2-adrenoceptor agonists.

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5 July 2018

Midazolam inhibits proinflammatory mediators in the lipopolysaccharide-activated macrophage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Sedative and analgesic medications: risk factors for delirium and sleep disturbances in the critically ill.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Delirium: acute cognitive dysfunction in the critically ill.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Decreased duration of mechanical ventilation when comparing analgesia-based sedation using remifentanil with standard hypnotic-based sedation for up to 10 days in intensive care unit patients: a randomised trial [ISRCTN47583497].

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit

1 reference

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5 July 2018

ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens

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5 July 2018

The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects

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5 July 2018

The pathophysiology and treatment of sepsis

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5 July 2018

Resistance of macrophages to Mycobacterium avium is induced by alpha2-adrenergic stimulation.

1 reference

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5 July 2018

The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!

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5 July 2018

The revised CONSORT statement for reporting randomized trials: explanation and elaboration

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5 July 2018

Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials

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5 July 2018

Subgroup analysis and other (mis)uses of baseline data in clinical trials

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5 July 2018

The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Randomisation and baseline comparisons in clinical trials.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Benzodiazepines inhibit neutrophil chemotaxis and superoxide production in a stimulus dependent manner; PK-11195 antagonizes these effects.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

5 July 2018

Adrenergic mechanisms in infection. III. α- and β-receptor blocking agents in treatment

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5 July 2018

Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

29 October 2018

Cytokines and acute phase response in delirium

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887145

29 October 2018

Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.

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29 October 2018

A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients.

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29 October 2018

Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients

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29 October 2018

Effects of alpha- and beta-adrenergic agonists on Toxoplasma gondii infection in murine macrophages

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29 October 2018

Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype

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29 October 2018

Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats

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Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock.

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Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS).

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Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome.

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The impact of delirium in the intensive care unit on hospital length of stay

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Challenges of subgroup analyses in multinational clinical trials: experiences from the MERIT-HF trial

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Delirium in an intensive care unit: a study of risk factors.

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Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU).

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The effects of clonidine and dexmedetomidine on human neutrophil functions.

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Europe PubMed Central

30 July 2017

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1 reference

Europe PubMed Central

30 July 2017

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Europe PubMed Central

30 July 2017

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