Vancomycin resistance in enterococci: reprogramming of the D-ala-D-Ala ligases in bacterial peptidoglycan biosynthesis (Q33912915)

30 July 2017

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title

Vancomycin resistance in enterococci: reprogramming of the D-ala-D-Ala ligases in bacterial peptidoglycan biosynthesis (English)

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30 July 2017

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Healy VL

1

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30 July 2017

Lessard IA

2

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30 July 2017

Roper DI

3

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30 July 2017

Knox JR

4

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30 July 2017

Walsh CT

5

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30 July 2017

language of work or name

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1 May 2000

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30 July 2017

Chemistry and Biology

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30 July 2017

7

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30 July 2017

5

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30 July 2017

R109-19

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Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci

30 July 2017

1 reference

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The structure and mode of action of glycopeptide antibiotics of the vancomycin group

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7 January 2021

Genetics and mechanisms of glycopeptide resistance in enterococci

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Structure, biochemistry and mechanism of action of glycopeptide antibiotics

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Vancomycin resistance: decoding the molecular logic

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The crisis in antibiotic resistance

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Multiple-Antibiotic-Resistant Pathogenic Bacteria -- A Report on the Rockefeller University Workshop

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Hospital-acquired infections: diseases with increasingly limited therapies

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7 January 2021

Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci

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7 January 2021

Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance.

1 reference

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7 January 2021

Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.

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7 January 2021

Analysis of genes encoding D-alanine-D-alanine ligase-related enzymes in Enterococcus casseliflavus and Enterococcus flavescens

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7 January 2021

Association constants for the binding of vancomycin and teicoplanin to N-acetyl-D-alanyl-D-alanine and N-acetyl-D-alanyl-D-serine

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7 January 2021

Determinants for differential effects on D-Ala-D-lactate vs D-Ala-D-Ala formation by the VanA ligase from vancomycin-resistant enterococci

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7 January 2021

Active site mapping of Escherichia coli D-Ala-D-Ala ligase by structure-based mutagenesis

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7 January 2021

Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution

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7 January 2021

D-Alanyl-D-lactate and D-alanyl-D-alanine synthesis by D-alanyl-D-alanine ligase from vancomycin-resistant Leuconostoc mesenteroides. Effects of a phenylalanine 261 to tyrosine mutation.

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7 January 2021

A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli

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7 January 2021

Biotin carboxylase comes into the fold

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Enzyme-mononucleotide interactions: three different folds share common structural elements for ATP recognition

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A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity

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7 January 2021

On the intermediacy of carboxyphosphate in biotin-dependent carboxylations

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Formyl phosphate: a proposed intermediate in the reaction catalyzed by Escherichia coli PurT GAR transformylase

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7 January 2021

Identification of a common protease-sensitive region in D-alanyl-D-alanine and D-alanyl-D-lactate ligases and photoaffinity labeling with 8-azido ATP

1 reference

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7 January 2021

Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B

1 reference

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7 January 2021

Calculation of the pKa values for the ligands and side chains of Escherichia coli D-alanine:D-alanine ligase

1 reference

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7 January 2021

DdlN from vancomycin-producing Amycolatopsis orientalis C329.2 is a VanA homologue with D-alanyl-D-lactate ligase activity.

1 reference

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7 January 2021

D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB

1 reference

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7 January 2021

Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms

1 reference

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7 January 2021

Vancomycin-resistant Leuconostoc mesenteroides and Lactobacillus casei synthesize cytoplasmic peptidoglycan precursors that terminate in lactate

1 reference

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7 January 2021

Modification of peptidoglycan precursors is a common feature of the low-level vancomycin-resistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroide

1 reference

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7 January 2021

Enzymes of vancomycin resistance: the structure of D-alanine-D-lactate ligase of naturally resistant Leuconostoc mesenteroides

1 reference

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7 January 2021

Phenotypic and genotypic heterogeneity of glycopeptide resistance determinants in gram-positive bacteria

1 reference

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7 January 2021

Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase

1 reference

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7 January 2021

Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases

1 reference

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7 January 2021

Purification and characterization of the D-alanyl-D-alanine-adding enzyme from Escherichia coli

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7 January 2021

Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.

1 reference

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7 January 2021

Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine.

1 reference

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7 January 2021

Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147.

1 reference

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7 January 2021

Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors.

1 reference

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7 January 2021

Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum BM4174.

1 reference

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7 January 2021

The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance

1 reference

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7 January 2021

Mutational analysis of active-site residues of the enterococcal D-ala-D-Ala dipeptidase VanX and comparison with Escherichia coli D-ala-D-Ala ligase and D-ala-D-Ala carboxypeptidase VanY.

1 reference

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7 January 2021

The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147

1 reference

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7 January 2021

Identification of the DNA-binding site for the phosphorylated VanR protein required for vancomycin resistance in Enterococcus faecium

1 reference

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7 January 2021

Characterization and modelling of VanT: a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174.

1 reference

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7 January 2021

Synthesis and evaluation of inhibitors of bacterial D-alanine:D-alanine ligases

1 reference

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7 January 2021

Two-component signal transduction as a target for microbial anti-infective therapy

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7 January 2021

In vitro antibacterial activity of LY333328, a new semisynthetic glycopeptide

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7 January 2021

Quinupristin/dalfopristin: therapeutic potential for vancomycin-resistant enterococcal infections

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7 January 2021

3D structure of ramoplanin: a potent inhibitor of bacterial cell wall synthesis

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7 January 2021

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

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7 January 2021

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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7 January 2021

Identification of the dadX gene coding for the predominant isozyme of alanine racemase in Escherichia coli K12

1 reference

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7 January 2021

The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both ?-alanyl-?-alanine and ?-alanyl-?-lactate ligases

1 reference

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7 January 2021

10.1016/S1074-5521(00)00116-2

Identifiers

DOI

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30 July 2017

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