Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol (Q33900859)

29 July 2017

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title

Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol (English)

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29 July 2017

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C J Hillard

1

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29 July 2017

1 April 2000

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Prostaglandins and Other Lipid Mediators

29 July 2017

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29 July 2017

61

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29 July 2017

3-18

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29 July 2017

1-2

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Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Molecular cloning of a human cannabinoid receptor which is also expressed in testis

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

A second endogenous cannabinoid that modulates long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

N-acylated glycerophospholipids and their derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

The N-acylation-phosphodiesterase pathway and cell signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

N-arachidonylethanolamine (anandamide) formation from N-arachidonylphosphatidylethanolamine in rat brain membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: involvement of Ca(2+)-dependent transacylase and phosphodiesterase activities

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Accumulation of various N-acylethanolamines including N-arachidonoylethanolamine (anandamide) in cadmium chloride-administered rat testis

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Catabolism of N-acylethanolamine phospholipids by dog brain preparations.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Enzymology of mammalian phospholipases D: in vitro studies.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

N-acylphosphatidylethanolamine-hydrolysing phospholipase D lacks the ability to transphosphatidylate.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Characterization of glutamate-induced formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cultured neocortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Formation of N-acyl-phosphatidylethanolamines and N-acetylethanolamines: proposed role in neurotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

GC/MS analysis of anandamide and quantification of N-arachidonoylphosphatidylethanolamides in various brain regions, spinal cord, testis, and spleen of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Alternative pathways of anandamide biosynthesis in rat testes.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Alterations of fatty acyl turnover in macrophage glycerolipids induced by stimulation. Evidence for enhanced recycling of arachidonic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Metabolism of unique diarachidonoyl and linoleoylarachidonoyl species of ethanolamine and choline phosphoglycerides in rat testes

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Potential biosynthetic connections between the two cannabimimetic eicosanoids, anandamide and 2-arachidonoyl-glycerol, in mouse neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Enzymatic formation of fatty acid amides of ethanolamine by rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Reversible hydrolysis and synthesis of anandamide demonstrated by recombinant rat fatty-acid amide hydrolase.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: is 2-arachidonoylglycerol a possible vasomodulator?

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Anandamide hydrolysis by human cells in culture and brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma ‘anandamide amidohydrolase’

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Chemical characterization of a family of brain lipids that induce sleep

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamide

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Anandamide amidohydrolase of porcine brain: cDNA cloning, functional expression and site-directed mutagenesis(1).

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Identification of two serine residues involved in catalysis by fatty acid amide hydrolase

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Demonstration of monoamine oxidase type B in serotonergic and type A in noradrenergic neurons in the cat dorsal pontine tegmentum by an improved histochemical technique

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Structural determinants for recognition and translocation by the anandamide transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Functional role of high-affinity anandamide transport, as revealed by selective inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Control of pain initiation by endogenous cannabinoids.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Identification and characterization of a prostaglandin transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Identification of cannabinoid receptors in cultures of rat cerebellar granule cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Production and physiological actions of anandamide in the vasculature of the rat kidney.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Effects of anandamide on cannabinoid receptors in rat brain membranes.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Cannabinoid receptor stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding in rat brain membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Marihuana-induced embryotoxicity in the rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Effects of anandamide on gestation in pregnant rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Anandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Cannabinoids reduce fertility of sea urchin sperm

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Further evidence for the presence of cannabinoid CB1 receptors in mouse vas deferens

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Cannabinoid ligand-receptor signaling in the mouse uterus

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Cannabinoid receptor localization in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Inhibition of histamine-stimulated gastric acid secretion by Δ9-tetrahydrocannabinol in rat isolated stomach

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Delta9-tetrahydrocannabinol inhibits gastric motility in the rat through cannabinoid CB1 receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Kinetic studies of food intake and sucrose solution preference by rats treated with low doses of delta9-tetrahydrocannabinol

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Cannabinoids and appetite stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Cannabinoid inhibition of guinea-pig intestinal peristalsis via inhibition of excitatory and activation of inhibitory neural pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2800%2900051-4

7 January 2021

10.1016/S0090-6980(00)00051-4

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10785538