DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association (Q33897815)

29 July 2017

DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association (English)

1 reference

29 July 2017

0 references

Sean M Green

1

1 reference

29 July 2017

H Jerome Coyne

series ordinal

2

1 reference

29 July 2017

Lawrence P McIntosh

series ordinal

3

1 reference

29 July 2017

Barbara J Graves

series ordinal

4

1 reference

29 July 2017

language of work or name

English

0 references

publication date

16 April 2010

1 reference

29 July 2017

9

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

29 July 2017

285

1 reference

29 July 2017

24

1 reference

29 July 2017

18496-18504

1 reference

Crystal Structure of Mouse Elf3 C-terminal DNA-binding Domain in Complex with Type II TGF-β Receptor Promoter DNA

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

DNA specificity determinants associate with distinct transcription factor functions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Different domains of the transcription factor ELF3 are required in a promoter-specific manner and multiple domains control its binding to DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

5 July 2018

The many faces of SAM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Derepression by depolymerization; structural insights into the regulation of Yan by Mae.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Native interface of the SAM domain polymer of TEL.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The ETS domain transcription factor Elk-1 contains a novel class of repression domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Structural studies of Ets-1/Pax5 complex formation on DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The PEA3 Ets transcription factor comprises multiple domains that regulate transactivation and DNA binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The mechanism of phosphorylation-inducible activation of the ETS-domain transcription factor Elk-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

TEL is a sequence-specific transcriptional repressor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The TEL gene contributes to the pathogenesis of myeloid and lymphoid leukemias by diverse molecular genetic mechanisms.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Characterization of the cooperative function of inhibitory sequences in Ets-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The Ets family of transcription factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881775

Molecular characterization of the B-box protein-protein interaction motif of the ETS-domain transcription factor Elk-1.

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096958

Inhibitory module of Ets-1 allosterically regulates DNA binding through a dipole-facilitated phosphate contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096958

DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096958

TEL, a putative tumor suppressor, induces apoptosis and represses transcription of Bcl-XL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096958

Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096958

Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096958

Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1)

21 January 2018

1 reference

12 December 2020

The ETS-domain transcription factor family

1 reference

12 December 2020

Diversity in structure and function of the Ets family PNT domains

1 reference

12 December 2020

Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix

1 reference

12 December 2020

Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

1 reference

12 December 2020

Specificity within the ets family of transcription factors

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.096958

1 reference

29 July 2017

1 reference

29 July 2017

1 reference