Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis (Q33896755)

29 July 2017

title

Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis (English)

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29 July 2017

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1

Mikhail V Blagosklonny

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29 July 2017

publication date

18 April 2010

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29 July 2017

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29 July 2017

volume

2

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29 July 2017

issue

4

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29 July 2017

page(s)

177-182

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Rapamycin extends maximal lifespan in cancer-prone mice

29 July 2017

cites work

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Biodemography of human ageing

5 July 2018

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mTOR's role in ageing: protein synthesis or autophagy?

5 July 2018

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Growth and aging: a common molecular mechanism

5 July 2018

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Validation of anti-aging drugs by treating age-related diseases

5 July 2018

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Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

5 July 2018

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Ageing populations: the challenges ahead

5 July 2018

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

5 July 2018

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mTOR regulates memory CD8 T-cell differentiation

5 July 2018

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Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor

5 July 2018

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5 July 2018

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Growth stimulation leads to cellular senescence when the cell cycle is blocked

5 July 2018

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Prevention of cancer by inhibiting aging

5 July 2018

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An anti-aging drug today: from senescence-promoting genes to anti-aging pill

5 July 2018

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Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition

5 July 2018

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TOR signaling in growth and metabolism

5 July 2018

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Infection, inflammation, height, and longevity

5 July 2018

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Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts

5 July 2018

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Inflammatory exposure and historical changes in human life-spans

5 July 2018

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Upstream and downstream of mTOR

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

Demography. Broken limits to life expectancy

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

Increase of maximum life-span in Sweden, 1861-1999.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster.

5 July 2018

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TOR-driven aging: speeding car without brakes

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

Oral rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: inhibitory effect on monocyte chemotaxis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27 Kip1 -independent pathway

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

Protective Effect of the Immunosuppressant Sirolimus Against Aortic Atherosclerosis In Apo E-Deficient Mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881507

29 October 2018

Identifiers

DOI

10.18632/AGING.100139

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PMC publication ID

2881507

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29 July 2017

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