Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition? (Q33892398)

29 July 2017

Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition? (English)

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29 July 2017

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8

Manon van Engeland

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29 July 2017

Tom van Wezel

12

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author name string

Eddy H J van Roon

1

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29 July 2017

Marjo van Puijenbroek

2

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29 July 2017

Anneke Middeldorp

3

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29 July 2017

Ronald van Eijk

4

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29 July 2017

Emile J de Meijer

5

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29 July 2017

Dianhdra Erasmus

6

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29 July 2017

Kim A D Wouters

7

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29 July 2017

Jan Oosting

9

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29 July 2017

Frederik J Hes

10

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29 July 2017

Carli M J Tops

11

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29 July 2017

Judith M Boer

13

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29 July 2017

Hans Morreau

14

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29 July 2017

language of work or name

English

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publication date

5 May 2010

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29 July 2017

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29 July 2017

10

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29 July 2017

180

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https://scigraph.springernature.com/pub.10.1186/1471-2407-10-180

29 July 2017

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cites work

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Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers

5 July 2018

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The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer

5 July 2018

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Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer

5 July 2018

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Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas.

5 July 2018

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GADD45A does not promote DNA demethylation

5 July 2018

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Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

5 July 2018

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5 July 2018

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An elaborate pathway required for Ras-mediated epigenetic silencing

5 July 2018

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Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancer

5 July 2018

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Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

5 July 2018

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5 July 2018

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Two colons-two cancers: paradigm shift and clinical implications

5 July 2018

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Development of a fluorescent multiplex assay for detection of MSI-High tumors

5 July 2018

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Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas

5 July 2018

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Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1.

5 July 2018

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Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability

5 July 2018

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Chromosomal imbalances in the colorectal carcinomas with microsatellite instability

5 July 2018

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P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.

5 July 2018

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Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a

5 July 2018

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Accounting for human polymorphisms predicted to affect protein function

5 July 2018

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Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis

5 July 2018

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5 July 2018

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Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification

5 July 2018

1 reference

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Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression.

5 July 2018

1 reference

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Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin

5 July 2018

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A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

5 July 2018

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COBRA: a sensitive and quantitative DNA methylation assay

5 July 2018

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Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

5 July 2018

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Genes involved in hereditary nonpolyposis colorectal carcinoma

5 July 2018

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Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1.

5 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

MLH1 Germline Epimutations as a Factor in Hereditary Nonpolyposis Colorectal Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

Inheritance of a Cancer-AssociatedMLH1Germ-Line Epimutation

21 January 2018

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https://api.crossref.org/works/10.1186%2F1471-2407-10-180

Germline epimutation of MLH1 in individuals with multiple cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

Conserved DNA methylation in Gadd45a(-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

Chromosomal instability in microsatellite-unstable and stable colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G > T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880297

A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880297

Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880297

Large genomic rearrangements and germline epimutations in Lynch syndrome

29 October 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-10-180

MLH1 germline epimutations in selected patients with early-onset non-polyposis colorectal cancer

21 January 2018

1 reference

12 December 2020

Evidence for heritable predisposition to epigenetic silencing of MLH1

1 reference

12 December 2020

Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome

1 reference

12 December 2020

Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC

1 reference

12 December 2020

1 reference

12 December 2020

Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2407-10-180

1 reference

Dimensions Publication ID

29 July 2017

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2407-10-180

9 September 2019

1 reference

29 July 2017

1 reference