Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial. (Q33875160)

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English	Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial.	scientific article

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9 March 2020

Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial (English)

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9 March 2020

phase I clinical trial

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vector-borne disease

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vaccinia virus

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Stefania Capone

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Lucy Dorrell

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Emma-Jo Hayton

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Annie Rose

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Umar Ibrahimsa

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Mariarosaria Del Sorbo

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Alison Crook

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Antony P Black

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Tomáš Hanke

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9 July 2014

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9 March 2020

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9 March 2020

e101591

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9 July 2014

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1 reference

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Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study

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Conserved immunogens in prime-boost strategies for the next-generation HIV-1 vaccines

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Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.

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Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine

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Absence of systemic toxicity changes following intramuscular administration of novel pSG2.HIVconsv DNA, ChAdV63.HIVconsv and MVA.HIVconsv vaccines to BALB/c mice

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28 July 2018

Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults

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Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design

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Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: a phase I randomised Trial in HIV-uninfected Indian volunteers

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28 July 2018

ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans

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A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults

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28 July 2018

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1 reference

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Superior induction of T cell responses to conserved HIV-1 regions by electroporated alphavirus replicon DNA compared to that with conventional plasmid DNA vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090156

28 July 2018

Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector

1 reference

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28 July 2018

Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species

1 reference

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28 July 2018

Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine

1 reference

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28 July 2018

Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors

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Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate

1 reference

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28 July 2018

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.

1 reference

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28 July 2018

Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive

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Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

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Design and pre-clinical evaluation of a universal HIV-1 vaccine

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Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine

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HIV vaccines: new frontiers in vaccine development

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Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis

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MVA as a vector for vaccines against HIV-1.

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28 July 2018

DNA vaccines against human immunodeficiency virus type 1.

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28 July 2018

Quantitative adenovirus neutralization assays based on the secreted alkaline phosphatase reporter gene: application in epidemiologic studies and in the design of adenovector vaccines

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Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.

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Reply to Richie and Villasante

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12 December 2020

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10.1371/JOURNAL.PONE.0101591

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9 March 2020

2014PLoSO...9j1591H

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9 March 2020

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