Structural and biochemical studies of retroviral proteases (Q33857432)

29 July 2017

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title

Structural and biochemical studies of retroviral proteases (English)

1 reference

29 July 2017

A Wlodawer

1

1 reference

PubMed ID

10708846

29 July 2017

A Gustchina

series ordinal

2

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PubMed ID

10708846

29 July 2017

language of work or name

English

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publication date

1 March 2000

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Biochimica et Biophysica Acta

29 July 2017

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29 July 2017

1477

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29 July 2017

16-34

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29 July 2017

1-2

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Database of three-dimensional structures of HIV proteinases

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Recent advances in the design of HIV proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Current knowledge and future prospects for the use of HIV protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure-based inhibitors of HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure and Function of Retroviral Proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Inhibitors of HIV-1 protease: a major success of structure-assisted drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Complete nucleotide sequence of the AIDS virus, HTLV-III

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Retroviral protease-like sequence in the yeast transposon Ty 1

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Active human immunodeficiency virus protease is required for viral infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Murine leukemia virus maturation: protease region required for conversion from "immature" to "mature" core form and for virus infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Central core domain of retroviral integrase is responsible for target site selection

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

The structure and function of the aspartic proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

A structural model for the retroviral proteases.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Possible role of some groups in the structure and function of HIV-1 protease as revealed by molecular modeling studies

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

A Consensus Template for the Aspartic Proteinase Fold

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

On the supersecondary structure of acid proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Is the pseudo-dyad in retroviral proteinase monomers structural or evolutionary?

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structural alignment of retroviral protease sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Crystal structure of a retroviral protease proves relationship to aspartic protease family

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure of the aspartic protease from Rous sarcoma retrovirus refined at 2-A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structural studies of the retroviral proteinase from avian myeloblastosis associated virus

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Alternative native flap conformation revealed by 2.3 A resolution structure of SIV proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Domain flexibility in retroviral proteases: structural implications for drug resistant mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Comparison of inhibitor binding in HIV-1 protease and in non-viral aspartic proteases: the role of the flap

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure of equine infectious anemia virus proteinase complexed with an inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structural basis for specificity of retroviral proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

HIV protease as an inhibitor target for the treatment of AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Inhibition and catalytic mechanism of HIV-1 aspartic protease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Analysis of the structure of chemically synthesized HIV-1 protease complexed with a hexapeptide inhibitor. Part I: Crystallographic refinement of 2 A data.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure of form III crystals of bovine pancreatic trypsin inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Energy calculations and analysis of HIV-1 protease-inhibitor crystal structures.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Expression, characterisation and mutagenesis of the aspartic proteinase from equine infectious anaemia virus

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

On the size of the active site in proteases. I. Papain

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Kinetic and modeling studies of S3-S3' subsites of HIV proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Subsite preferences of retroviral proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Coevolution and subsite decomposition for the design of resistance-evading HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Studies on the substrate specificity of the proteinase of equine infectious anemia virus using oligopeptide substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Analysis of substrate cleavage by recombinant protease of human T cell leukaemia virus type 1 reveals preferences and specificity of binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Identification of amino acid residues of the retroviral aspartic proteinases important for substrate specificity and catalytic efficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Studies on the role of the S4 substrate binding site of HIV proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Ionization states of the catalytic residues in HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Crystal structure of a tethered dimer of HIV-1 proteinase complexed with an inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Activity of tethered human immunodeficiency virus 1 protease containing mutations in the flap region of one subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Altered Rous sarcoma virus Gag polyprotein processing and its effects on particle formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

The regulation of sequential processing of HIV-1 Gag by the viral protease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Proteolysis of an active site peptide of lactate dehydrogenase by human immunodeficiency virus type 1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Programming the Rous sarcoma virus protease to cleave new substrate sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Comparative properties of feline immunodeficiency virus (FIV) and human immunodeficiency virus type 1 (HIV-1) proteinases prepared by total chemical synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Identification of proteolytic processing sites within the Gag and Pol polyproteins of feline immunodeficiency virus.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900267-8

7 January 2021

10.1016/S0167-4838(99)00267-8

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10708846