The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease Neuropathology (Q33839157)

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23 March 2020

review article

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4 August 2020

26 August 2020

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease Neuropathology (English)

1 reference

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23 March 2020

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cell surface receptor

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23 March 2020

Viviana Triaca

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Valentina Latina

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Maria Teresa Ciotti

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23 March 2020

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Nadia Canu

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23 March 2020

Valentina Sposato

5

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23 March 2020

Veronica Corsetti

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Cinzia Severini

7

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Pietro Calissano

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26 August 2020

International Journal of Molecular Sciences

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Creative Commons Attribution

23 March 2020

copyright license

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cites work

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease

5 July 2018

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5 July 2018

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5 July 2018

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c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein.

5 July 2018

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Axonal transport defects: a common theme in neurodegenerative diseases

5 July 2018

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The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia

5 July 2018

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Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease.

5 July 2018

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Going the distance, or not, with neurotrophin signals

5 July 2018

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Alzheimer's disease and NGF signaling

5 July 2018

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Sortilin is essential for proNGF-induced neuronal cell death

5 July 2018

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The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?

5 July 2018

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Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease.

5 July 2018

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The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.

5 July 2018

1 reference

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Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Tau is essential to beta -amyloid-induced neurotoxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Neurotrophins: to cleave or not to cleave

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Receptor binding, internalization, and retrograde transport of neurotrophic factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Nerve growth factor signaling, neuroprotection, and neural repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Nerve growth factor rapidly induces prolonged acetylcholine release from cultured basal forebrain neurons: differentiation between neuromodulatory and neurotrophic influences.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Neurotrophin signal transduction in the nervous system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Aberrant tau phosphorylation and neurite retraction during NGF deprivation in PC12 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmented cultures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Structural correlates of cognition in dementia: quantification and assessment of synapse change.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Signal transduction by the neurotrophin receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Axonal transport in neurological disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Quantitative assessment of cortical synaptic density in Alzheimer's disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5486140

Retrograde support of neuronal survival without retrograde transport of nerve growth factor

5 July 2018

1 reference

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Neurobiology. TRK makes the retrograde

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Up-regulation of sortilin mediated by amyloid-β and p75(NTR): safety lies in the middle course

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

APP processing is regulated by cytoplasmic phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Amyloid precursor protein cytoplasmic domain with phospho-Thr668 accumulates in Alzheimer's disease and its transgenic models: a role to mediate interaction of Abeta and tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Caspase cleavage of members of the amyloid precursor family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Alzheimer's disease: the amyloid hypothesis on trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Phosphorylation and cleavage of tau in non-AD tauopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Passive immunization targeting the N-terminal region of phosphorylated tau (residues 68-71) improves spatial memory in okadaic acid induced tauopathy model rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Identification of a tau promoter region mediating tissue-specific-regulated expression in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Endogenous Aβ causes cell death via early tau hyperphosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS18061319

Nerve growth factor increases the synthesis and release of acetylcholine and the expression of vesicular acetylcholine transporter in primary cultured rat embryonic septal cells

21 January 2018

1 reference

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NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals

29 October 2018

1 reference

12 December 2020

The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons

1 reference

12 December 2020

Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein

1 reference

12 December 2020

Nerve growth factor and Alzheimer's disease

1 reference

12 December 2020

Abeta, tau and ApoE4 in Alzheimer's disease: the axonal connection

1 reference

12 December 2020

The pathological process underlying Alzheimer's disease in individuals under thirty

1 reference

12 December 2020

NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway

1 reference

12 December 2020

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS18061319

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28632177%20AND%20SRC:MED&resulttype=core&format=json

release_aim7nqnswrbcnpfebggiw6bili

23 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/aim7nqnswrbcnpfebggiw6bili

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28632177%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

28632177

1 reference