Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells (Q33825109)

29 July 2017

Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells (English)

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29 July 2017

Alexandra K Leamy

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29 July 2017

Robert A Egnatchik

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29 July 2017

Masakazu Shiota

3

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29 July 2017

Pavlina T Ivanova

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29 July 2017

David S Myers

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29 July 2017

H Alex Brown

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29 July 2017

Jamey D Young

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29 July 2017

23 May 2014

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Journal of Lipid Research

29 July 2017

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29 July 2017

55

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29 July 2017

7

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29 July 2017

1478-1488

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describes a project that uses

29 July 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4076085/fullTextXML

inferred from PubMed Central ID database lookup

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Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes

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Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease

4 July 2018

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4 July 2018

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4 July 2018

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Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model

4 July 2018

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Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

4 July 2018

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Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscle

4 July 2018

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4 July 2018

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Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

4 July 2018

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Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis

4 July 2018

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Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells

4 July 2018

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Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase

4 July 2018

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4 July 2018

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Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line

4 July 2018

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Signal integration in the endoplasmic reticulum unfolded protein response

4 July 2018

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4 July 2018

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Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

4 July 2018

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

4 July 2018

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Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

4 July 2018

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Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

4 July 2018

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4 July 2018

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

4 July 2018

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

4 July 2018

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Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153).

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Palmitate-induced apoptosis can occur through a ceramide-independent pathway

4 July 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M050237

Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death

21 January 2018

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https://api.crossref.org/works/10.1194%2FJLR.M050237

Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin

21 January 2018

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Decrease in membrane phospholipid unsaturation induces unfolded protein response

21 January 2018

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Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

21 January 2018

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Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

21 January 2018

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Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells

21 January 2018

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Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

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Modulation of lipid-induced ER stress by fatty acid shape

21 January 2018

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12 December 2020

Effect of fatty acids on physical properties of microsomes from isolated perfused rat liver

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12 December 2020

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

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12 December 2020

Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance

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12 December 2020

Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis

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12 December 2020

Identifiers

DOI

10.1194/JLR.M050237

1 reference

29 July 2017

1 reference

29 July 2017

1 reference